Cardiovascular disease, with atherosclerosis as the major underlying factor, remains the
leading cause of death worldwide. It is well established that cholesterol ester-enriched foam …

After activation, cells of the myeloid lineage undergo robust metabolic transitions, as well as
discrete epigenetic changes, that can dictate both ongoing and future inflammatory …

The cGAS-STING pathway mediates cytoplasmic DNA-triggered innate immunity. STING
activation is initiated by cyclic-GMP-AMP (cGAMP)-induced translocation from the …

e160 Arterioscler Thromb Vasc Biol September 2018 were actively exported to the
cytoplasm with exportin-5 in a Ran-GTP–dependent manner. In the cytoplasm, the transition …

Lysosomes are of major importance for the regulation of cellular cholesterol homeostasis.
Food-derived cholesterol and cholesterol esters contained within lipoproteins are delivered …

Objective—Defective autophagy in macrophages leads to pathological processes that
contribute to atherosclerosis, including impaired cholesterol metabolism and defective …

The endoplasmic reticulum (ER) is an organelle that is responsible for many essential
subcellular processes. Interconnected narrow tubules at the periphery and thicker sheet-like …

The prevention and treatment of cardiovascular diseases (CVD) has largely focused on
lowering circulating LDL cholesterol, yet a significant burden of atherosclerotic disease …

Lipoprotein cholesterol is delivered to the limiting membrane of late endosomes/lysosomes
(LELs) by Niemann-Pick C1 (NPC1). However, the mechanism of cholesterol transport from …

The human genome encodes thousands of long noncoding RNAs (lncRNAs), the majority of
which are poorly conserved and uncharacterized. Here we identify a primate-specific …