From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

T Efferth - Seminars in cancer biology, 2017 - Elsevier
Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria
and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been …

Oxidative stress in malaria and artemisinin combination therapy: Pros and Cons

RA Kavishe, JB Koenderink, M Alifrangis - The FEBS journal, 2017 - Wiley Online Library
Artemisinin‐based combination therapy (ACT) has been adopted as a strategy to mitigate
multidrug resistance to antimalarial monotherapies. ACT combines the rapid and effective …

Multi-omics approaches to improve malaria therapy

M Zhou, A Varol, T Efferth - Pharmacological Research, 2021 - Elsevier
Malaria contributes to the most widespread infectious diseases worldwide. Even though
current drugs are commercially available, the ever-increasing drug resistance problem by …

[HTML][HTML] Efficacy and safety of artemisinin-based combination therapy, and molecular markers for artemisinin and piperaquine resistance in Mainland Tanzania

MA Kakolwa, MK Mahende, DS Ishengoma… - Malaria journal, 2018 - Springer
Background Artemisinin-based combination therapy (ACT) is the first-line anti-malarial
treatment of uncomplicated malaria in most malaria endemic countries, including Tanzania …

[HTML][HTML] Efficacy and safety of artemisinin-based combination therapies for the treatment of uncomplicated malaria in pediatrics: a systematic review and meta-analysis

W Shibeshi, G Alemkere, A Mulu… - BMC Infectious Diseases, 2021 - Springer
Background Malaria is a major cause of morbidity and mortality in pediatrics in malaria
endemic areas. Artemisinin-based combination therapies (ACTs) are the drugs of choice for …

[HTML][HTML] Efficacy and safety of artemether-lumefantrine for the treatment of uncomplicated malaria and prevalence of Pfk13 and Pfmdr1 polymorphisms after a decade …

DS Ishengoma, CI Mandara, F Francis, E Talundzic… - Malaria journal, 2019 - Springer
Abstract Background The World Health Organization recommends regular therapeutic
efficacy studies (TES) to monitor the performance of first and second-line anti-malarials. In …

[HTML][HTML] Heme-dependent ER stress apoptosis: a mechanism for the selective toxicity of the dihydroartemisinin, NSC735847, in colorectal cancer cells

AEM Elhassanny, E Soliman, M Marie… - Frontiers in …, 2020 - frontiersin.org
Colorectal cancer (CRC) is a leading cause of cancer death in the United States. Artemisinin
derivatives, including the dihydroartemisinin (DHA) monomers, are widely used as clinical …

[HTML][HTML] Therapeutic efficacy trial of artemisinin-based combination therapy for the treatment of uncomplicated malaria and investigation of mutations in k13 propeller …

AM Dorkenoo, D Yehadji, YM Agbo, Y Layibo… - Malaria journal, 2016 - Springer
Abstract Background Since 2005, the Togo National Malaria Control Programme has
recommended two different formulations of artemisinin-based combination therapy (ACT) …

[HTML][HTML] Efficacy and safety of dihydroartemisinin–piperaquine versus artemether–lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in …

DG Assefa, ED Zeleke, D Bekele, HA Tesfahunei… - Malaria journal, 2021 - Springer
Background The emergence of artemisinin resistance in Southeast Asia and Plasmodium
falciparum kelch13 propeller gene mutations in sub-Saharan African pose the greatest …

[HTML][HTML] Safety and therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria at Shecha health centre, Arba …

K Gubae, H Mohammed, H Sime, H Hailgiorgis… - Malaria Journal, 2023 - Springer
Abstract Background In 2004, Ethiopia adopted artemether-lumefantrine (AL, Coartem®) as
first-line treatment for the management of uncomplicated Plasmodium falciparum malaria …