Estrogen receptor β (ERβ) is closely related to breast cancer (BC) progression. Traditional
concepts regard ERβ as a tumor suppressor. As studies show the carcinogenic effect of …

Significance: In eukaryotes, autophagy represents a highly evolutionary conserved process,
through which macromolecules and cytoplasmic material are degraded into lysosomes and …

Estrogen receptor alpha (ERα, encoded by ESR1) is a well-characterized transcription factor
expressed in more than 75% of breast tumors and is the key biomarker to direct endocrine …

Breast cancer is a highly heterogeneous disease. Tamoxifen is a selective estrogen receptor
(ER) modulator and is mainly indicated for the treatment of breast cancer in postmenopausal …

ABSTRACT SIRT3, the major deacetylase in mitochondria, plays a crucial role modulating
ROS production and scavenging by regulating key proteins implicated in mitochondrial …

Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most
common cancer among women worldwide. Challenges facing the diagnosis and treatment …

Breast cancer is the most diagnosed diseases and the second-leading cause of death in
females, among which the estrogen receptor positive (ER+) patients are more common of all …

Breast cancer is the most common malignancy in women of developed countries. The aim of
this study was to investigate the effects of the phytoestrogen genistein on the inflammatory …

Excessive adiposity (particularly visceral fat mass) increases the risks of developing
metabolic syndrome. Women have lower deposit of visceral fat than men, and this pattern …

Cisplatin is a platinum-based chemotherapeutic drug used in the standard treatment of
various solid cancers including testicular, bladder, head and neck, cervical and ovarian …