Angiotensin II type 1 receptor antagonists (ARBs) have become an important drug class in
the treatment of hypertension and heart failure and the protection from diabetic nephropathy …

Angiotensin II receptor blockers (ARBs) represent a new class of effective and well tolerated
orally active antihypertensive agents. Recent clinical trials have shown the added benefits of …

Cytochrome P450 2C9 (CYP2C9) is one of the most abundant CYP enzymes in the human
liver. CYP2C9 metabolizes more than 100 therapeutic drugs, including tolbutamide …

Objective Recent reports have shown that genetic polymorphisms in organic anion
transporting polypeptide (OATP) 1B1 have an effect on the pharmacokinetics of drugs …

Drug-induced kidney injury is a major clinical problem and causes drug attrition in the
pharmaceutical industry. To better predict drug-induced kidney injury, kidney in vitro cultures …

Many of the estimated 50 million Americans with high blood pressure receive medications
for hypertension and for other conditions, placing them at risk for adverse drug interactions …

A high-performance liquid chromatographic (HPLC) method for the determination of
valsartan in human plasma is reported. The assay is based on protein precipitation with …

Insomnia, an inability to initiate or maintain sleep, affects approximately one-third of the
American population. Conventional benzodiazepines, such as triazolam and midazolam …

Valsartan is a new potent, highly selective and orally active antihypertensive drug belonging
to the family of angiotensin II type 1 receptor antagonists. Valsartan has much greater affinity …

Valsartan is known to be excreted largely as unchanged compound and is minimally
metabolized in man. Although the only notable metabolite is 4-hydroxyvaleryl metabolite (4 …