Multiplex ligation‐dependent probe amplification (MLPA) is a commonly used technique for
determining relative DNA sequence dosage (or copy number) in a complex DNA sample …

The severe acute respiratory syndrome (SARS), caused by a novel coronavirus (SARS-
CoV), resulted in substantial morbidity, mortality, and economic losses during the 2003 …

Disruption of neurotransmitter vesicle dynamics (transport, capacity, release) has been
implicated in a variety of neurodegenerative and neuropsychiatric conditions. Here, we …

The most severe form of autosomal dominant polycystic kidney disease occurs in patients
with mutations in the gene (PKD1) encoding polycystin-1 (PC1). PC1 is a complex polytopic …

Expression of the p16Ink4a tumor suppressor gene, a sensor of oncogenic stress, is up-
regulated by a variety of potentially oncogenic stimuli in cultured primary cells. However …

Background New advances in high-throughput technologies have allowed for the massive
analysis of genomic data, providing new opportunities for the characterization of the …

Hyperuricaemia is a disease associated with elevated serum uric acid content, which has
emerged rapidly in recent decades. The drugs used to treat clinical hyperuricaemia have …

Background Recombinant protein production in Escherichia coli cells is a complex process,
where among other parameters, plasmid copy number, structural and segregational stability …

Pichia pastoris is a preferred host for heterologous protein production. Expression cassettes
are usually integrated into the genome of this methylotrophic yeast. This manuscript …

NRAS mutations are a common oncogenic event in skin cancer, occurring frequently in
congenital nevi and malignant melanoma. To study the role of NRAS in zebrafish, a …