[HTML][HTML] Euglycemic diabetic ketoacidosis and sodium-glucose cotransporter-2 inhibitors: a focused review of pathophysiology, risk factors, and triggers

MR Somagutta, K Agadi, N Hange, MS Jain, E Batti… - Cureus, 2021 - ncbi.nlm.nih.gov
Diabetic ketoacidosis (DKA) is an acute and significant life-threatening complication of
diabetes. The association of sodium-glucose cotransporter-2 inhibitors (SGLT2i) with …

Sodium-glucose cotransporter inhibitors as antidiabetic drugs: current development and future perspectives

R Maccari, R Ottanà - Journal of medicinal chemistry, 2022 - ACS Publications
Sodium-glucose cotransporter 2 (SGLT-2) inhibitors (gliflozins) represent the most recently
approved class of oral antidiabetic drugs. SGLT-2 overexpression in diabetic patients …

A complete review of empagliflozin: Most specific and potent SGLT2 inhibitor used for the treatment of type 2 diabetes mellitus

G Chawla, KK Chaudhary - … & Metabolic Syndrome: Clinical Research & …, 2019 - Elsevier
Abstract Sodium-glucose co-transporter 2 (SGLT2) inhibitors are the latest class of drugs to
be introduced for the treatment of type 2 diabetes mellitus (T2DM). They reduce …

The importance of SGLT-2 inhibitors as both the prevention and the treatment of diabetic cardiomyopathy

K Kowalska, P Wilczopolski, D Buławska, E Młynarska… - Antioxidants, 2022 - mdpi.com
According to the 2021 report of the International Diabetes Federation (IDF), there have been
approximately 573 million cases of type 2 diabetes mellitus (T2DM) among adults, which …

Exploring novel lead scaffolds for SGLT2 inhibitors: Insights from machine learning and molecular dynamics simulations

Y Yu, Y Xia, G Liang - International Journal of Biological Macromolecules, 2024 - Elsevier
Abstract Sodium-glucose cotransporter 2 (SGLT2) plays a pivotal role in mediating glucose
reabsorption within the renal filtrate, representing a well-known target in type 2 diabetes and …

Mechanisms and perspectives of sodium-glucose co-transporter 2 inhibitors in heart failure

Q Zeng, Q Zhou, W Liu, Y Wang, X Xu… - Frontiers in …, 2021 - frontiersin.org
Heart failure (HF) is a common complication or late-stage manifestation of various heart
diseases. Numerous risk factors and underlying causes may contribute to the occurrence …

GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review

R De Masi, S Orlando - International Journal of Molecular Sciences, 2022 - mdpi.com
Glycans are one of the four fundamental macromolecular components of living matter, and
they are highly regulated in the cell. Their functions are metabolic, structural and modulatory …

Diabetic Ketoacidosis.

BJ Lowie, MC Bond - Emergency Medicine Clinics of North America, 2023 - europepmc.org
This article reviews the most current literature on diabetic ketoacidosis, including how to
make the diagnosis and management. It discusses euglycemic diabetic ketoacidosis and the …

Investigating the Cardiovascular Benefits of Dapagliflozin: Vasodilatory Effect on Isolated Rat Coronary Arteries

S Choi, CE Haam, S Byeon, EY Oh, SK Choi… - International Journal of …, 2023 - mdpi.com
Dapagliflozin, a sodium–glucose co-transporter 2 (SGLT2) inhibitor, is an antidiabetic
medication that reduces blood glucose. Although it is well known that dapagliflozin has …

Ameliorative effect of polydatin on hyperglycemia and renal injury in streptozotocin-induced diabetic rats

L Wang, L Huang, N Li, J Miao, W Liu… - Cellular and Molecular …, 2019 - cellmolbiol.org
To investigate the effect of polydatin on glucose transporter, blood glucose homeostasis and
renal injury in streptozotocin (STZ)-induced diabetic rats. The in vitro inhibitory effect of …