Traumatic and nontraumatic spinal cord injury: pathological insights from neuroimaging

G David, S Mohammadi, AR Martin… - Nature Reviews …, 2019 - nature.com
Pathophysiological changes in the spinal cord white and grey matter resulting from injury
can be observed with MRI techniques. These techniques provide sensitive markers of …

The current state-of-the-art of spinal cord imaging: applications

CA Wheeler-Kingshott, PW Stroman, JM Schwab… - Neuroimage, 2014 - Elsevier
A first-ever spinal cord imaging meeting was sponsored by the International Spinal
Research Trust and the Wings for Life Foundation with the aim of identifying the current state …

Disability, atrophy and cortical reorganization following spinal cord injury

P Freund, N Weiskopf, NS Ward, C Hutton, A Gall… - Brain, 2011 - academic.oup.com
The impact of traumatic spinal cord injury on structural integrity, cortical reorganization and
ensuing disability is variable and may depend on a dynamic interaction between the severity …

Demyelination and degeneration in the injured human spinal cord detected with diffusion and magnetization transfer MRI

J Cohen-Adad, MM El Mendili, S Lehéricy, PF Pradat… - Neuroimage, 2011 - Elsevier
Characterizing demyelination/degeneration of spinal pathways in traumatic spinal cord
injured (SCI) patients is crucial for assessing the prognosis of functional rehabilitation. Novel …

Functional brain reorganization after spinal cord injury: systematic review of animal and human studies

R Nardone, Y Höller, F Brigo, M Seidl, M Christova… - Brain research, 2013 - Elsevier
Plastic changes of neural circuits occur after spinal cord injury (SCI) at various level of the
central nervous system. In this review we will focus on delineating the pathophysiological …

Progressive neurodegeneration following spinal cord injury: implications for clinical trials

G Ziegler, P Grabher, A Thompson, D Altmann… - Neurology, 2018 - AAN Enterprises
Objective To quantify atrophy, demyelination, and iron accumulation over 2 years following
acute spinal cord injury and to identify MRI predictors of clinical outcomes and determine …

Spinal cord imaging in amyotrophic lateral sclerosis: historical concepts—novel techniques

MM El Mendili, G Querin, P Bede, PF Pradat - Frontiers in neurology, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease
with no effective disease modifying therapies at present. Spinal cord degeneration is a …

Tracking sensory system atrophy and outcome prediction in spinal cord injury

P Grabher, MF Callaghan, J Ashburner… - Annals of …, 2015 - Wiley Online Library
Objective In patients with subacute spinal cord injury (SCI), the motor system undergoes
progressive structural changes rostral to the lesion, which are associated with motor …

Association of pain and CNS structural changes after spinal cord injury

CR Jutzeler, E Huber, MF Callaghan, R Luechinger… - Scientific Reports, 2016 - nature.com
Traumatic spinal cord injury (SCI) has been shown to trigger structural atrophic changes
within the spinal cord and brain. However, the relationship between structural changes and …

Involvement of spinal sensory pathway in ALS and specificity of cord atrophy to lower motor neuron degeneration

J Cohen-Adad, MME Mendili… - … Lateral Sclerosis and …, 2013 - Taylor & Francis
Our objective was to demonstrate that ALS patients have sensory pathway involvement and
that local cord atrophy reflects segmental lower motor neuron involvement. Twenty-nine ALS …