Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Purinergic signalling, ie ATP as an extracellular signalling molecule and cotransmitter in
both peripheral and central neurons, is involved in the physiology of neurotransmission and …

Background According to our previous study, microglia P2X4 receptors (P2X4Rs) play a
pivotal role in the central sensitization of chronic migraine (CM). However, the molecular …

The principle functions of neuroinflammation are to limit tissue damage and promote tissue
repair in response to pathogens or injury. While neuroinflammation has utility …

Extracellular nucleosides and nucleotides have widespread functions in responding to
physiological stress. The “purinome” encompasses 4 G-protein-coupled receptors (GPCRs) …

The physiopathology and neurotransmission of pain are of an owe inspiring complexity. Our
ability to satisfactorily suppress neuropathic or other forms of chronic pain is limited. The …

Trigeminal neuropathic pain is a chronic pain condition caused by damage or inflammation
of the trigeminal nerve or its branches, with both peripheral and central nervous system …

Diabetes mellitus (DM), an emerging chronic epidemic, contributes to mortality and morbidity
around the world. Diabetic cardiac autonomic neuropathy (DCAN) is one of the most …

Background The mechanism underlying migraine chronification remains unclear. Central
sensitization may account for this progression. The microglia P2X4 receptor (P2X4R) plays a …

This review article presents a collection of tool compounds that selectively block and are
recommended for studying P2Y and P2X receptor subtypes, investigating their roles in …