Specialized peripheral sensory neurons known as nociceptors alert us to potentially
damaging stimuli at the skin by detecting extremes in temperature and pressure and injury …

The study of diverse animal groups allows us to discern the evolution of the neurobiology of
nociception. Nociception functions as an important alarm system alerting the individual to …

Sensory neurons of the dorsal root ganglion (DRG) are critical for maintaining tissue
homeostasis by sensing and initiating responses to stimuli. While most preclinical studies of …

Distinct types of dorsal root ganglion sensory neurons may have unique contributions to
chronic pain. Identification of primate sensory neuron types is critical for understanding the …

The dorsal horn of the spinal cord is critical to processing distinct modalities of noxious and
innocuous sensation, but little is known of the neuronal subtypes involved, hampering efforts …

Mechanical stimuli drive many physiological processes, including touch and pain sensation,
hearing, and blood pressure regulation. Mechanically activated (MA) cation channel …

The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

The somatosensory system mediates fundamental physiological functions, including the
senses of touch, pain and proprioception. This variety of functions is matched by a diverse …

During the past two decades, an important focus of pain research has been the study of
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity …

In order to survive, animals must avoid injury and be able to detect potentially damaging
stimuli via nociceptive mechanisms. If the injury is accompanied by a negative affective …