Nociceptors: the sensors of the pain pathway
AE Dubin, A Patapoutian - The Journal of clinical …, 2010 - Am Soc Clin Investig
Specialized peripheral sensory neurons known as nociceptors alert us to potentially
damaging stimuli at the skin by detecting extremes in temperature and pressure and injury …
damaging stimuli at the skin by detecting extremes in temperature and pressure and injury …
Comparative physiology of nociception and pain
LU Sneddon - Physiology, 2017 - journals.physiology.org
The study of diverse animal groups allows us to discern the evolution of the neurobiology of
nociception. Nociception functions as an important alarm system alerting the individual to …
nociception. Nociception functions as an important alarm system alerting the individual to …
Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function
M Jung, M Dourado, J Maksymetz, A Jacobson… - Nature …, 2023 - nature.com
Sensory neurons of the dorsal root ganglion (DRG) are critical for maintaining tissue
homeostasis by sensing and initiating responses to stimuli. While most preclinical studies of …
homeostasis by sensing and initiating responses to stimuli. While most preclinical studies of …
Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain
Distinct types of dorsal root ganglion sensory neurons may have unique contributions to
chronic pain. Identification of primate sensory neuron types is critical for understanding the …
chronic pain. Identification of primate sensory neuron types is critical for understanding the …
Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types
The dorsal horn of the spinal cord is critical to processing distinct modalities of noxious and
innocuous sensation, but little is known of the neuronal subtypes involved, hampering efforts …
innocuous sensation, but little is known of the neuronal subtypes involved, hampering efforts …
Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels
Mechanical stimuli drive many physiological processes, including touch and pain sensation,
hearing, and blood pressure regulation. Mechanically activated (MA) cation channel …
hearing, and blood pressure regulation. Mechanically activated (MA) cation channel …
Transient receptor potential cation channels in disease
The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …
channels that are mostly permeable to both monovalent and divalent cations. The 28 …
Molecular mechanisms of mechanotransduction in mammalian sensory neurons
P Delmas, J Hao, L Rodat-Despoix - Nature Reviews Neuroscience, 2011 - nature.com
The somatosensory system mediates fundamental physiological functions, including the
senses of touch, pain and proprioception. This variety of functions is matched by a diverse …
senses of touch, pain and proprioception. This variety of functions is matched by a diverse …
Role of the immune system in chronic pain
F Marchand, M Perretti, SB McMahon - Nature Reviews Neuroscience, 2005 - nature.com
During the past two decades, an important focus of pain research has been the study of
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity …
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity …
Evolution of nociception and pain: evidence from fish models
LU Sneddon - … Transactions of the Royal Society B, 2019 - royalsocietypublishing.org
In order to survive, animals must avoid injury and be able to detect potentially damaging
stimuli via nociceptive mechanisms. If the injury is accompanied by a negative affective …
stimuli via nociceptive mechanisms. If the injury is accompanied by a negative affective …