MYB oncoproteins: emerging players and potential therapeutic targets in human cancer
Y Cicirò, A Sala - Oncogenesis, 2021 - nature.com
MYB transcription factors are highly conserved from plants to vertebrates, indicating that
their functions embrace fundamental mechanisms in the biology of cells and organisms. In …
their functions embrace fundamental mechanisms in the biology of cells and organisms. In …
Celastrol: a spectrum of treatment opportunities in chronic diseases
The identification of new bioactive compounds derived from medicinal plants with significant
therapeutic properties has attracted considerable interest in recent years. Such is the case of …
therapeutic properties has attracted considerable interest in recent years. Such is the case of …
Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
X Liu, P Zhao, X Wang, L Wang, Y Zhu, Y Song… - Journal of Experimental …, 2019 - Springer
Background Celastrol, a triterpene compound derived from the traditional Chinese medicine
Tripterygium wilfordii, has been reported to possess potential antitumor activity towards …
Tripterygium wilfordii, has been reported to possess potential antitumor activity towards …
[HTML][HTML] Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies
C Wang, S Dai, X Zhao, Y Zhang, L Gong, K Fu… - Biomedicine & …, 2023 - Elsevier
Celastrol is a pentacyclic triterpenoid extracted from the traditional Chinese medicine
Tripterygium wilfordii Hook F., which has multiple pharmacological activities. In particular …
Tripterygium wilfordii Hook F., which has multiple pharmacological activities. In particular …
Gold Nanorods Exhibit Intrinsic Therapeutic Activity via Controlling N6-Methyladenosine-Based Epitranscriptomics in Acute Myeloid Leukemia
Reprograming the N 6-methyladenosine (m6A) landscape is a promising therapeutic
strategy against recalcitrant leukemia. In this study, we synthesized gold nanorods (GNRs) …
strategy against recalcitrant leukemia. In this study, we synthesized gold nanorods (GNRs) …
Pediatric low-grade gliomas: implications of the biologic era
For the past decade, it has been recognized that pediatric low-grade gliomas (LGGs) and
glial-neuronal tumors carry distinct molecular alterations with resultant aberrant intracellular …
glial-neuronal tumors carry distinct molecular alterations with resultant aberrant intracellular …
Transcription factor inhibition: lessons learned and emerging targets
A Chen, AN Koehler - Trends in molecular medicine, 2020 - cell.com
Transcription factors have roles at focal points in signaling pathways, controlling many
normal cellular processes, such as cell growth and proliferation, metabolism, apoptosis …
normal cellular processes, such as cell growth and proliferation, metabolism, apoptosis …
Targeting acute myeloid leukemia by drug-induced c-MYB degradation
V Walf-Vorderwülbecke, K Pearce, T Brooks, M Hubank… - Leukemia, 2018 - nature.com
Despite advances in our understanding of the molecular basis for particular subtypes of
acute myeloid leukemia (AML), effective therapy remains a challenge for many individuals …
acute myeloid leukemia (AML), effective therapy remains a challenge for many individuals …
Peptidomimetic blockade of MYB in acute myeloid leukemia
K Ramaswamy, L Forbes, G Minuesa, T Gindin… - Nature …, 2018 - nature.com
Aberrant gene expression is a hallmark of acute leukemias. MYB-driven transcriptional
coactivation with CREB-binding protein (CBP)/P300 is required for acute lymphoblastic and …
coactivation with CREB-binding protein (CBP)/P300 is required for acute lymphoblastic and …
[HTML][HTML] A TFIID-SAGA perturbation that targets MYB and suppresses acute myeloid leukemia
Targeting of general coactivators is an emerging strategy to interfere with oncogenic
transcription factors (TFs). However, coactivator perturbations often lead to pleiotropic effects …
transcription factors (TFs). However, coactivator perturbations often lead to pleiotropic effects …