Metastasis formation is a complex process, involving multiple crucial steps, which are
controlled by different regulatory mechanisms. In this context, the contribution of cancer …

Cancer cells exist in a complex ecosystem with numerous other cell types in the tumor
microenvironment (TME). The composition of this tumor/TME ecosystem will vary at each …

Modelling adult diseases to understand their aetiology and progression, and to develop new
therapies, is a major challenge for medical biology. We are excited by new efforts in the …

Objective: The metabolism of cholesterol has been found to be closely related to the
proliferation, invasion, and metastasis of tumors. The purpose of this study was to investigate …

Background In the current era of effective adjuvant therapies and de-escalation of surgery,
distinguishing which patients with high-risk stage II melanoma are at increased risk of …

Melanoma, a highly prevalent cancer worldwide, exhibits remarkable diversity and plasticity,
with the adverse prognosis of advanced melanoma remaining a focal point of investigation …

The advent of large-scale sequencing in both development and disease has identified large
numbers of candidate genes that may be linked to important phenotypes. Validating the …