A rapid simple point-of-care assay for the detection of SARS-CoV-2 neutralizing antibodies

P Kongsuphol, H Jia, HL Cheng, Y Gu… - Communications …, 2021 - nature.com
Abstract Background Neutralizing antibodies (NAbs) prevent pathogens from infecting host
cells. Detection of SARS-CoV-2 NAbs is critical to evaluate herd immunity and monitor …

Stabilization of the SARS-CoV-2 spike receptor-binding domain using deep mutational scanning and structure-based design

D Ellis, N Brunette, KHD Crawford, AC Walls… - Frontiers in …, 2021 - frontiersin.org
The unprecedented global demand for SARS-CoV-2 vaccines has demonstrated the need
for highly effective vaccine candidates that are thermostable and amenable to large-scale …

Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice

R Salzer, JJ Clark, M Vaysburd, VT Chang… - FEBS …, 2021 - Wiley Online Library
The COVID‐19 pandemic, caused by the SARS‐CoV‐2 coronavirus, has triggered a
worldwide health emergency. Here, we show that ferritin‐like Dps from hyperthermophilic …

Mechanism of a COVID-19 nanoparticle vaccine candidate that elicits a broadly neutralizing antibody response to SARS-CoV-2 variants

YN Zhang, J Paynter, C Sou, T Fourfouris, Y Wang… - Science …, 2021 - science.org
Vaccines that induce potent neutralizing antibody (NAb) responses against emerging
variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are essential for …

Scalable, methanol‐free manufacturing of the SARS‐CoV‐2 receptor‐binding domain in engineered Komagataella phaffii

NC Dalvie, AM Biedermann… - Biotechnology and …, 2022 - Wiley Online Library
Prevention of COVID‐19 on a global scale will require the continued development of high‐
volume, low‐cost platforms for the manufacturing of vaccines to supply ongoing demand …

Are hamsters a suitable model for evaluating the immunogenicity of RBD-based anti-COVID-19 subunit vaccines?

IA Merkuleva, DN Shcherbakov, MB Borgoyakova… - Viruses, 2022 - mdpi.com
Currently, SARS-CoV-2 spike receptor-binding-domain (RBD)-based vaccines are
considered one of the most effective weapons against COVID-19. During the first step of …

[HTML][HTML] Recombinant protein subunit SARS-CoV-2 vaccines formulated with CoVaccine HT™ adjuvant induce broad, Th1 biased, humoral and cellular immune …

CY Lai, A To, TAS Wong, MM Lieberman, DE Clements… - Vaccine: X, 2021 - Elsevier
The speed at which several COVID-19 vaccines went from conception to receiving FDA and
EMA approval for emergency use is an achievement unrivaled in the history of vaccine …

[HTML][HTML] A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates

NC Dalvie, LH Tostanoski, SA Rodriguez-Aponte… - bioRxiv, 2021 - ncbi.nlm.nih.gov
Vaccines against SARS-CoV-2 have been distributed at massive scale in developed
countries, and have been effective at preventing COVID-19. Access to vaccines is limited …

Alum: CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity

E Nanishi, F Borriello, TR O'Meara, ME McGrath… - bioRxiv, 2021 - biorxiv.org
Global deployment of vaccines that can provide protection across several age groups is still
urgently needed to end the COVID-19 pandemic especially for low-and middle-income …

A cGAMP-containing hydrogel for prolonged SARS-CoV-2 RBD subunit vaccine exposure induces a broad and potent humoral response

V Böhnert, EC Gale, LJ Lahey, J Yan, AE Powell… - bioRxiv, 2021 - biorxiv.org
The SARS-CoV-2 virus spike protein, specifically its receptor binding domain (RBD), has
emerged as a promising target for generation of neutralizing antibodies. Although the RBD …