Nanoparticle drug delivery systems and their applications as targeted therapies for triple negative breast cancer

X Kong, Y Qi, X Wang, R Jiang, J Wang, Y Fang… - Progress in Materials …, 2023 - Elsevier
The therapeutic effect of highly malignant triple negative breast cancer (TNBC) is negatively
affected by the formation of tumor cell resistant clone and the severe toxicity of …

The role of glutamate receptors in the regulation of the tumor microenvironment

S Koda, J Hu, X Ju, G Sun, S Shao, RX Tang… - Frontiers in …, 2023 - frontiersin.org
Glutamate, as one of the most important carbon sources in the TCA cycle, is central in
metabolic processes that will subsequently influence tumor progression. Several factors can …

Brain‐targeted liposomes loaded with monoclonal antibodies reduce alpha‐synuclein aggregation and improve behavioral symptoms in Parkinson's disease

M Sela, M Poley, P Mora‐Raimundo… - Advanced …, 2023 - Wiley Online Library
Monoclonal antibodies (mAbs) hold promise in treating Parkinson's disease (PD), although
poor delivery to the brain hinders their therapeutic application. In the current study, it is …

Beta-blockade enhances anthracycline control of metastasis in triple-negative breast cancer

A Chang, E Botteri, RD Gillis, L Löfling, CP Le… - Science Translational …, 2023 - science.org
Beta-adrenergic blockade has been associated with improved cancer survival in patients
with triple-negative breast cancer (TNBC), but the mechanisms of these effects remain …

NMDAR antagonists suppress tumor progression by regulating tumor-associated macrophages

D Yuan, J Hu, X Ju, EM Putz, S Zheng… - Proceedings of the …, 2023 - National Acad Sciences
Neurotransmitter receptors are increasingly recognized to play important roles in anti-tumor
immunity. The expression of the ion channel N-methyl-D-aspartate receptor (NMDAR) on …

Perineural invasion in pancreatic ductal adenocarcinoma: from molecules towards drugs of clinical relevance

F Selvaggi, E Melchiorre, I Casari, S Cinalli, M Cinalli… - Cancers, 2022 - mdpi.com
Simple Summary A few types of cancers are currently as challenging and difficult to defeat
as pancreatic ductal adenocarcinoma. Several reasons contribute to the complexity of this …

Recent progress in nanocarrier-based drug delivery systems for antitumour metastasis

S Peng, X Yuan, H Li, Y Wei, B Zhou, G Ding… - European Journal of …, 2023 - Elsevier
Tumour metastasis is one of the major factors leading to poor prognosis as well as lower
survival among cancer patients. A number of studies investigating the inhibition of tumour …

[HTML][HTML] Genomic instability drives tumorigenesis and metastasis and its implications for cancer therapy

S Guo, X Zhu, Z Huang, C Wei, J Yu, L Zhang… - Biomedicine & …, 2023 - Elsevier
Genetic instability can be caused by external factors and may also be associated with
intracellular damage. At the same time, there is a large body of research investigating the …

Fluorescent multifunctional organic nanoparticles for drug delivery and bioimaging: a tutorial review

G Vargas-Nadal, M Köber, A Nsamela, F Terenziani… - Pharmaceutics, 2022 - mdpi.com
Fluorescent organic nanoparticles (FONs) are a large family of nanostructures constituted by
organic components that emit light in different spectral regions upon excitation, due to the …

Targeted intervention in nerve–cancer crosstalk enhances pancreatic cancer chemotherapy

J Qin, J Liu, Z Wei, X Li, Z Chen, J Li, W Zheng… - Nature …, 2024 - nature.com
Nerve–cancer crosstalk has gained substantial attention owing to its impact on tumour
growth, metastasis and therapy resistance. Effective therapeutic strategies targeting tumour …