Structure-based prediction of T cell receptor: peptide-MHC interactions
P Bradley - Elife, 2023 - elifesciences.org
The regulatory and effector functions of T cells are initiated by the binding of their cell-
surface T cell receptor (TCR) to peptides presented by major histocompatibility complex …
surface T cell receptor (TCR) to peptides presented by major histocompatibility complex …
Application of T cell receptor (TCR) repertoire analysis for the advancement of cancer immunotherapy
K Joshi, M Milighetti, BM Chain - Current Opinion in Immunology, 2022 - Elsevier
Highlights•TCR repertoire analysis as a tool to advance cancer immunotherapy.•
Computational methods are used to understand TCR repertoire characteristics.•Both TCR …
Computational methods are used to understand TCR repertoire characteristics.•Both TCR …
Engineering the T cell receptor for fun and profit: Uncovering complex biology, interrogating the immune system, and targeting disease
AM Rosenberg, BM Baker - Current opinion in structural biology, 2022 - Elsevier
T cell receptors (TCRs) orchestrate cellular immunity by recognizing peptide antigens bound
and presented by major histocompatibility complex (MHC) proteins. Due to the TCR's central …
and presented by major histocompatibility complex (MHC) proteins. Due to the TCR's central …
HLA3DB: comprehensive annotation of peptide/HLA complexes enables blind structure prediction of T cell epitopes
The class I proteins of the major histocompatibility complex (MHC-I) display epitopic
peptides derived from endogenous proteins on the cell surface for immune surveillance …
peptides derived from endogenous proteins on the cell surface for immune surveillance …
Predicting T cell receptor antigen specificity from structural features derived from homology models of receptor-peptide-major histocompatibility complexes
The physical interaction between the T cell receptor (TCR) and its cognate antigen causes T
cells to activate and participate in the immune response. Understanding this physical …
cells to activate and participate in the immune response. Understanding this physical …
A structural-based machine learning method to classify binding affinities between TCR and peptide-MHC complexes
The activation of T cells is triggered by the interactions of T cell receptors (TCRs) with their
epitopes, which are peptides presented by major histocompatibility complex (MHC) on the …
epitopes, which are peptides presented by major histocompatibility complex (MHC) on the …
Techniques for Theoretical Prediction of Immunogenic Peptides
R Friedman - Encyclopedia, 2024 - mdpi.com
Definition Small peptides are an important component of the vertebrate immune system.
They are important molecules for distinguishing proteins that originate in the host from …
They are important molecules for distinguishing proteins that originate in the host from …
TCRpcDist: estimating TCR physico-chemical similarity to analyze repertoires and predict specificities
MAS Perez, J Chiffelle, S Bobisse, F Mayol-Rullan… - bioRxiv, 2023 - biorxiv.org
Approaches to analyse and cluster TCR repertoires to reflect antigen specificity are critical
for the diagnosis and prognosis of immune-related diseases and the development of …
for the diagnosis and prognosis of immune-related diseases and the development of …
Dynamics-based peptide–mhc binding optimization by a convolutional variational autoencoder: a use-case model for Castelo
An unsolved challenge in the development of antigen-specific immunotherapies is
determining the optimal antigens to target. Comprehension of antigen–major …
determining the optimal antigens to target. Comprehension of antigen–major …
3pHLA-score improves structure-based peptide-HLA binding affinity prediction
Binding of peptides to Human Leukocyte Antigen (HLA) receptors is a prerequisite for
triggering immune response. Estimating peptide-HLA (pHLA) binding is crucial for peptide …
triggering immune response. Estimating peptide-HLA (pHLA) binding is crucial for peptide …