Recently, necroptosis, as a programmed cell death pathway, has drawn much attention as it
has been implicated in multiple pathologies, especially in the field of inflammatory diseases …

Necroptosis, or regulated necrosis, is an important type of programmed cell death in addition
to apoptosis. Necroptosis induction leads to cell membrane disruption, inflammation and …

Pseudokinases are members of the protein kinase superfamily but signal primarily through
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …

Necroptosis is a regulated caspase-independent form of necrotic cell death that results in an
inflammatory phenotype. This process contributes profoundly to the pathophysiology of …

Mixed Lineage Kinase domain-Like pseudokinase (MLKL) is implicated in a broad range of
diseases due to its role as the ultimate effector of necroptosis and has therefore emerged as …

Necroptosis, an important form of programmed cell death (PCD), is a highly regulated
caspase-independent type of cell death that plays a critical role in the pathophysiology of …

The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely
implicated in human disease, including renal, pulmonary, gut and skin inflammatory …

The pseudokinase complement of the human kinase superfamily consists of approximately
60 signaling proteins, which lacks one or more of the amino acids typically required to …

Many cancer patients frequently fail to respond to anti-cancer treatment due to therapy
resistance which is the major obstacle towards curative cancer treatment. Therefore …

As an alternative pathway of controlled cell death, necroptosis can be triggered by tumor
necrosis factor via the kinases RIPK1/RIPK3 and the effector protein mixed-lineage kinase …