Macroautophagy (hereafter called autophagy) is a highly conserved physiological process
that degrades over-abundant or damaged organelles, large protein aggregates and …

Macroautophagy, initially described as a non-selective nutrient recycling process, is
essential for the removal of multiple cellular components. In the past three decades …

The structural integrity and functional stability of organelles are prerequisites for the viability
and responsiveness of cells. Dysfunction of multiple organelles is critically involved in the …

The selective clearance of organelles by autophagy is critical for the regulation of cellular
homeostasis in organisms from yeast to humans. Removal of damaged organelles clears …

The conjugation of the 76 amino acid protein ubiquitin to other proteins can alter the
metabolic stability or non-proteolytic functions of the substrate. Once attached to a substrate …

Selective autophagy of organelles is critical for cellular differentiation, homeostasis, and
organismal health. Autophagy of the ER (ER-phagy) is implicated in human neuropathy but …

In recent decades, the role of the peroxisome in physiology and disease conditions has
become increasingly important. Together with the mitochondria and other cellular …

Primary adrenal insufficiency is life threatening and can present alone or in combination with
other comorbidities. Here, we have described a primary adrenal insufficiency syndrome and …

USP 30 is an integral protein of the outer mitochondrial membrane that counteracts PINK 1
and Parkin‐dependent mitophagy following acute mitochondrial depolarisation. Here, we …

Peroxisomes carry out many key functions related to lipid and reactive oxygen species
(ROS) metabolism. The fundamental importance of peroxisomes for health in humans is …