Studies of the choroid plexus lag behind those of the more widely known blood-brain barrier,
despite a much longer history. This review has two overall aims. The first is to outline long …

The amyloid precursor protein (APP) plays a central role in the pathophysiology of
Alzheimer's disease in large part due to the sequential proteolytic cleavages that result in …

The aging process correlates with a progressive failure in the normal cellular and organ
functioning; these alterations are aggravated in Alzheimer's disease (AD). In both aging and …

The choroid plexus is an epithelial–endothelial vascular convolute within the ventricular
system of the vertebrate brain. It consists of epithelial cells, fenestrated blood vessels, and …

Animal models aim to replicate the symptoms, the lesions or the cause (s) of Alzheimer
disease. Numerous mouse transgenic lines have now succeeded in partially reproducing its …

Cells that have evolved to produce large quantities of secreted proteins to serve the
integrated functions of complex multicellular organisms are equipped to compensate for …

One of the characteristic hallmarks of Alzheimer's disease (AD) is an accumulation of
amyloid β (Aβ) leading to plaque formation and toxic oligomeric Aβ complexes. Besides the …

The choroid plexus is composed of epithelial cells resting on a basal lamina. These cells
produce the cerebrospinal fluid (CSF), which has many functions including rendering …

Neuronal and synaptic degeneration are the best pathological correlates for memory decline
in Alzheimer's disease (AD). Although the accumulation of soluble low-molecular-weight …

Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver
and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other …