Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases

LD Nguyen, BE Ehrlich - EMBO molecular medicine, 2020 - embopress.org
Chemotherapy is a life‐saving treatment for cancer patients, but also causes long‐term
cognitive impairment, or “chemobrain”, in survivors. However, several challenges, including …

Doxorubicin-induced cognitive impairment: the mechanistic insights

J Du, A Zhang, J Li, X Liu, S Wu, B Wang… - Frontiers in …, 2021 - frontiersin.org
Chemotherapy can significantly prolong the survival of patients with breast cancer;
Nevertheless, the majority of patients receiving chemotherapy such as doxorubicin may …

Doxorubicin and cisplatin induced cognitive impairment: the possible mechanisms and interventions

B Ongnok, N Chattipakorn, SC Chattipakorn - Experimental neurology, 2020 - Elsevier
Chemotherapy has significantly increased the number of cancer survivors. However,
chemotherapy itself carries various adverse effects that limit the efficacy of treatment and …

Mechanisms of chemotherapy-induced neurotoxicity

H Was, A Borkowska, A Bagues, L Tu… - Frontiers in …, 2022 - frontiersin.org
Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been
extensively used in the clinic as the main cancer treatment either alone or as an adjuvant …

Chemotherapy-induced cognitive impairment and hippocampal neurogenesis: a review of physiological mechanisms and interventions

MJ Sekeres, M Bradley-Garcia… - International journal of …, 2021 - mdpi.com
A wide range of cognitive deficits, including memory loss associated with hippocampal
dysfunction, have been widely reported in cancer survivors who received chemotherapy …

[HTML][HTML] Plausible biochemical mechanisms of chemotherapy-induced cognitive impairment (“chemobrain”), a condition that significantly impairs the quality of life of …

X Ren, D Boriero, L Chaiswing, S Bondada… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Increasing numbers of cancer patients survive and live longer than five years after therapy,
but very often side effects of cancer treatment arise at same time. One of the side effects …

Animal models of chemotherapy-induced cognitive decline in preclinical drug development

J John, M Kinra, J Mudgal, GL Viswanatha… - …, 2021 - Springer
Rationale Chemotherapy-induced cognitive impairment (CICI), chemobrain, and chemofog
are the common terms for mental dysfunction in a cancer patient/survivor under the influence …

Pharmacological rescue of cognitive function in a mouse model of chemobrain

LD Nguyen, TT Fischer, BE Ehrlich - Molecular Neurodegeneration, 2021 - Springer
Background After chemotherapy, many cancer survivors suffer from long-lasting cognitive
impairment, colloquially known as “chemobrain.” However, the trajectories of cognitive …

Dysregulation of cytokine mediated chemotherapy induced cognitive impairment

X Ren, DKS Clair, DA Butterfield - Pharmacological research, 2017 - Elsevier
One of the major complaints patients who survive cancer often make is chemotherapy
induced cognitive impairment (CICI), which survivors often call “chemo brain.” CICI is a side …

Polymeric mesoporous silica nanoparticles for enhanced delivery of 5-fluorouracil in vitro

T Moodley, M Singh - Pharmaceutics, 2019 - mdpi.com
There is a need for the improvement of conventional cancer treatment strategies by
incorporation of targeted and non-invasive procedures aimed to reduce side-effects, drug …