Anti-proliferative activity, molecular genetics, docking analysis, and computational calculations of uracil cellulosic aldehyde derivatives

AM Fahim, S Dacrory, GH Elsayed - Scientific Reports, 2023 - nature.com
In this study, the oxidation of microcrystalline cellulose using NaIO4 to yield the
corresponding cellulose aldehyde utilized microwave irradiation as a green tool, the …

Unexpected products using Biginelli reaction: Synthesis, antimicrobial potency, docking simulation, and DFT investigations of some new amidopyridines

NA Kheder, AM Fahim, NS Mahmoud… - Journal of Molecular …, 2024 - Elsevier
The Biginelli reaction of 3-oxo-N-(2-pyridyl) butanamide with thiourea (or urea) and some
aromatic aldehydes afforded new chemical skeletons containing tetrahydropyrimidine …

Synthesis and in-silico studies of some new thiazole carboxamide derivatives with theoretical investigation

N A. Kheder, H Ather, D R. Emam… - Polycyclic Aromatic …, 2024 - Taylor & Francis
Based on the tremendous pharmacological activities of compounds containing thiazole and
carboxamide moieties, the current study aims to prepare new series of thiazole, pyrazole …

Novel bis pyrimidine-pyrazolone and pyridinyl-4, 5-dihydropyrimido [2, 1 [1]-c, 1, 2, 4] triazepine utilized ultrasonic energy, anti-proliferative activity, docking simulation …

A Aboelnaga, S Soror, E Nassar, S Elabbady… - Journal of Molecular …, 2023 - Elsevier
Eco-friendly synthesis of novel bis heterocyclic compounds containing pyridine derivatives
utilized green tools such as ultrasonication energy. Moreover, the nucleophilic substitution of …

Designing a green poly (β-amino ester) for the delivery of nicotinamide drugs with biological activities and conducting a DFT investigation

MS Hashem, AM Fahim, FM Helaly - RSC advances, 2024 - pubs.rsc.org
The environmentally friendly polymerization process was carried out using microwave
irradiation without additional solvents or catalysts to produce poly (β-amino ester)(PβAE) …

Antimicrobial, anticancer activities, molecular docking, and DFT/B3LYP/LANL2DZ analysis of heterocyclic cellulose derivative and their Cu-complexes

AM Fahim, S Dacrory, AH Hashem, S Kamel - International Journal of …, 2024 - Elsevier
In this study, novel Cu-complexes of heterocyclic cellulose which were synthesized via the
reaction of carboxymethyl cellulose (CMC) from bagasse pulp with NH 2 NH 2 to give …

Exploring novel bromo heterocyclic scaffold and theoretical explanation of their biological actions

HEM Tolan, SA Abdelhamid, AM Fahim - Journal of Molecular Structure, 2024 - Elsevier
In this elucidation, we synthesized different heterocyclic compounds through (E)-1-(2‑bromo-
4-methylphenyl)-3-(4-bromophenyl) prop‑2-en-1-one (3) which is synthesized from the aldol …

Synthesis, X-ray, Hirshfeld surface analysis, computational investigations, electrochemical analysis, ADME investigations, and insecticidal activities utilized docking …

MA Shalaby, MH BinSabt, HM Al-Matar, SA Rizk… - Journal of Molecular …, 2025 - Elsevier
In this study, we synthesized the new 2, 4, 6-triaryl pyridine through reacting alkoxy chalcone
with ammonium acetate, followed by extensive characterization utilizing a variety of spectral …

Synthesis, chemical characterization, and anti-proliferative action of 1, 2, 4-triazole N-glycoside derivatives

HEM Tolan, AM Fahim, EHI Ismael - Egyptian Journal of Chemistry, 2024 - journals.ekb.eg
In this study, we have reacted the mercapto-N-phenyl-1, 2, 4-triazolothiazolo derivative 1a
with acetylated bromo galactose 2a to give the new O-acetylated N-phenyl-1, 2, 4-triazolo …

Synthesis and crystal structure of piperidinyl propanenitrile towards the preparation of piperidine based bioactive films for drug delivery applications

RA Mohamed-Ezzat, MS Hasanin, BM Kariuki… - Scientific Reports, 2025 - nature.com
Compounds containing the piperidine group are highly attractive as building blocks for
designing new drugs. Functionalized piperidines are of significant interest due to their …