Protein arginine methyltransferase (PRMT)-mediated arginine methylation is an important
post-transcriptional modification that regulates various cellular processes including …

Human papillomavirus (HPV) is the most prevalent sexually transmitted virus globally.
Persistent high‐risk HPV infection can result in cervical precancerous lesions and cervical …

Karyopherin α (KPNA) proteins are involved in nucleocytoplasmic trafficking and are critical
for protein subcellular localization. Recent studies have suggested that KPNA proteins are …

Nonalcoholic fatty liver disease (NAFLD) is substantiated by the reprogramming of liver
metabolic pathways that disrupts the homeostasis of lipid and glucose metabolism and thus …

A cascade of three enzymes, E1− E2− E3, is responsible for transferring ubiquitin to target
proteins, which controls many different aspects of cellular signaling. The role of the E2 has …

Yeast is an essential model organism for studying protein ubiquitination pathways; however,
identifying the direct substrates of E3 in the cell presents a challenge. Here, we present a …

共激活蛋白相关的精氨酸甲基转移酶1 (coactivator-associated arginine methyltransferase 1,
CARM1) 是蛋白质精氨酸甲基转移酶(protein arginine methyltransferase, PRMT) 家族的成员 …

The E3 ubiquitin (UB) ligase Parkin utilizes a Ring-Between-Ring (RBR) domain to mediate
the transfer of UB to its substrates to regulate diverse cellular functions, including …

Abstract RING finger protein 38 (RNF38) is a member of the RING family of E3 ubiquitin (UB)
ligases while HHARI is one of RBR family members: both regulate key processes in the cell …

Coactivator-associated arginine methyltransferase 1 (CARM1) is a member of the protein
arginine methyltransferase (PRMT) family, also known as PRMT4. In recent years, CARM1 …