Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

Mutations in metabolic enzymes, including isocitrate dehydrogenase 1 (IDH1) and IDH2, in
cancer strongly implicate altered metabolism in tumorigenesis. IDH1 and IDH2 catalyze the …

While the oxygen-dependent reversal of lysine N ɛ-methylation is well established, the
existence of bona fide N ω-methylarginine demethylases (RDMs) is controversial. Lysine …

Diffuse large B cell lymphoma (DLBCL) is a clinically and biologically heterogeneous
disease with a high proliferation rate. By integrating copy number data with transcriptional …

Most neurological diseases are associated with chronic inflammation initiated by the
activation of microglia, which produce cytotoxic and inflammatory factors. Signal transducers …

The iron-and 2-oxoglutarate-dependent oxygenases constitute a phylogenetically
conserved class of enzymes that catalyze hydroxylation reactions in humans by acting on …

In recent years, many studies have shown that histone methylation plays an important role in
maintaining the active and silent state of gene expression in human diseases. The Jumonji …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of
amyloid-β (Aβ) peptide in the hippocampus and frontal cortex of the brain, leading to …

Histone methylation is involved in the epigenetic control of immune responses and cellular
senescence. Jumonji domain-containing protein 3 (JMJD3), also called lysine-specific …

In prostate cancer, two different types of histone lysine demethylases (KDM), LSD1/KDM1
and JMJD2/KDM4, are coexpressed and colocalize with the androgen receptor. We …