Neural dedifferentiation in the aging brain
JD Koen, MD Rugg - Trends in cognitive sciences, 2019 - cell.com
Many cognitive abilities decline with age even in the absence of detectable pathology.
Recent evidence indicates that age-related neural dedifferentiation, operationalized in terms …
Recent evidence indicates that age-related neural dedifferentiation, operationalized in terms …
Cerebrovascular reactivity (CVR) MRI with CO2 challenge: a technical review
Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular reserve and provides
important information about vascular health in a range of brain conditions and diseases …
important information about vascular health in a range of brain conditions and diseases …
[HTML][HTML] Cerebrovascular reactivity measurement using magnetic resonance imaging: a systematic review
E Sleight, MS Stringer, I Marshall, JM Wardlaw… - Frontiers in …, 2021 - frontiersin.org
Cerebrovascular reactivity (CVR) magnetic resonance imaging (MRI) probes cerebral
haemodynamic changes in response to a vasodilatory stimulus. CVR closely relates to the …
haemodynamic changes in response to a vasodilatory stimulus. CVR closely relates to the …
Intracranial hemodynamic relationships in patients with cerebral small vessel disease
Objective To investigate cerebrovascular reactivity (CVR), blood flow, vascular and CSF
pulsatility, and their independent relationship with cerebral small vessel disease (SVD) …
pulsatility, and their independent relationship with cerebral small vessel disease (SVD) …
The effect of ageing on f MRI: Correction for the confounding effects of vascular reactivity evaluated by joint f MRI and MEG in 335 adults
In functional magnetic resonance imaging (fMRI) research one is typically interested in
neural activity. However, the blood‐oxygenation level‐dependent (BOLD) signal is a …
neural activity. However, the blood‐oxygenation level‐dependent (BOLD) signal is a …
Understanding variability in the BOLD signal and why it matters for aging
CL Grady, DD Garrett - Brain imaging and behavior, 2014 - Springer
Recent work in neuroscience supports the idea that variability in brain function is necessary
for optimal brain responsivity to a changing environment. In this review, we discuss a series …
for optimal brain responsivity to a changing environment. In this review, we discuss a series …
Non-BOLD contrast for laminar fMRI in humans: CBF, CBV, and CMRO2
Functional magnetic resonance imaging (fMRI) using the blood oxygenation level-
dependent (BOLD) contrast indirectly probes neuronal activity changes via evoked cerebral …
dependent (BOLD) contrast indirectly probes neuronal activity changes via evoked cerebral …
The relationship between age, neural differentiation, and memory performance
JD Koen, N Hauck, MD Rugg - Journal of Neuroscience, 2019 - Soc Neuroscience
Healthy aging is associated with decreased neural selectivity (dedifferentiation) in category-
selective cortical regions. This finding has prompted the suggestion that dedifferentiation …
selective cortical regions. This finding has prompted the suggestion that dedifferentiation …
Cerebrovascular reactivity mapping without gas challenges
Cerebrovascular reactivity (CVR), the ability of cerebral vessels to dilate or constrict, has
been shown to provide valuable information in the diagnosis and treatment evaluation of …
been shown to provide valuable information in the diagnosis and treatment evaluation of …
Separating vascular and neuronal effects of age on fMRI BOLD signals
KA Tsvetanov, RNA Henson… - … Transactions of the …, 2021 - royalsocietypublishing.org
Accurate identification of brain function is necessary to understand the neurobiology of
cognitive ageing, and thereby promote well-being across the lifespan. A common tool used …
cognitive ageing, and thereby promote well-being across the lifespan. A common tool used …