Neural dedifferentiation in the aging brain

JD Koen, MD Rugg - Trends in cognitive sciences, 2019 - cell.com
Many cognitive abilities decline with age even in the absence of detectable pathology.
Recent evidence indicates that age-related neural dedifferentiation, operationalized in terms …

Cerebrovascular reactivity (CVR) MRI with CO2 challenge: a technical review

P Liu, B Jill, H Lu - Neuroimage, 2019 - Elsevier
Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular reserve and provides
important information about vascular health in a range of brain conditions and diseases …

[HTML][HTML] Cerebrovascular reactivity measurement using magnetic resonance imaging: a systematic review

E Sleight, MS Stringer, I Marshall, JM Wardlaw… - Frontiers in …, 2021 - frontiersin.org
Cerebrovascular reactivity (CVR) magnetic resonance imaging (MRI) probes cerebral
haemodynamic changes in response to a vasodilatory stimulus. CVR closely relates to the …

Intracranial hemodynamic relationships in patients with cerebral small vessel disease

GW Blair, MJ Thrippleton, Y Shi, I Hamilton, M Stringer… - Neurology, 2020 - AAN Enterprises
Objective To investigate cerebrovascular reactivity (CVR), blood flow, vascular and CSF
pulsatility, and their independent relationship with cerebral small vessel disease (SVD) …

The effect of ageing on f MRI: Correction for the confounding effects of vascular reactivity evaluated by joint f MRI and MEG in 335 adults

KA Tsvetanov, RNA Henson, LK Tyler… - Human brain …, 2015 - Wiley Online Library
In functional magnetic resonance imaging (fMRI) research one is typically interested in
neural activity. However, the blood‐oxygenation level‐dependent (BOLD) signal is a …

Understanding variability in the BOLD signal and why it matters for aging

CL Grady, DD Garrett - Brain imaging and behavior, 2014 - Springer
Recent work in neuroscience supports the idea that variability in brain function is necessary
for optimal brain responsivity to a changing environment. In this review, we discuss a series …

Non-BOLD contrast for laminar fMRI in humans: CBF, CBV, and CMRO2

L Huber, K Uludağ, HE Möller - Neuroimage, 2019 - Elsevier
Functional magnetic resonance imaging (fMRI) using the blood oxygenation level-
dependent (BOLD) contrast indirectly probes neuronal activity changes via evoked cerebral …

The relationship between age, neural differentiation, and memory performance

JD Koen, N Hauck, MD Rugg - Journal of Neuroscience, 2019 - Soc Neuroscience
Healthy aging is associated with decreased neural selectivity (dedifferentiation) in category-
selective cortical regions. This finding has prompted the suggestion that dedifferentiation …

Cerebrovascular reactivity mapping without gas challenges

P Liu, Y Li, M Pinho, DC Park, BG Welch, H Lu - Neuroimage, 2017 - Elsevier
Cerebrovascular reactivity (CVR), the ability of cerebral vessels to dilate or constrict, has
been shown to provide valuable information in the diagnosis and treatment evaluation of …

Separating vascular and neuronal effects of age on fMRI BOLD signals

KA Tsvetanov, RNA Henson… - … Transactions of the …, 2021 - royalsocietypublishing.org
Accurate identification of brain function is necessary to understand the neurobiology of
cognitive ageing, and thereby promote well-being across the lifespan. A common tool used …