Rab proteins and the compartmentalization of the endosomal system
A Wandinger-Ness, M Zerial - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …
Role of Rab GTPases in membrane traffic and cell physiology
AH Hutagalung, PJ Novick - Physiological reviews, 2011 - journals.physiology.org
Intracellular membrane traffic defines a complex network of pathways that connects many of
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …
the membrane-bound organelles of eukaryotic cells. Although each pathway is governed by …
Stiff matrix induces exosome secretion to promote tumour growth
Tissue fibrosis and extracellular matrix (ECM) stiffening promote tumour progression. The
mechanisms by which ECM regulates its contacting cells have been extensively studied …
mechanisms by which ECM regulates its contacting cells have been extensively studied …
Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity
Macrophages play a pivotal role in tumor immunity. We report that reprogramming of
macrophages to tumor-associated macrophages (TAMs) promotes the secretion of …
macrophages to tumor-associated macrophages (TAMs) promotes the secretion of …
Rab27a and Rab27b control different steps of the exosome secretion pathway
M Ostrowski, NB Carmo, S Krumeich, I Fanget… - Nature cell …, 2010 - nature.com
Exosomes are secreted membrane vesicles that share structural and biochemical
characteristics with intraluminal vesicles of multivesicular endosomes (MVEs). Exosomes …
characteristics with intraluminal vesicles of multivesicular endosomes (MVEs). Exosomes …
The road to lysosome‐related organelles: Insights from Hermansky‐Pudlak syndrome and other rare diseases
Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …
Rabs and their effectors: achieving specificity in membrane traffic
BL Grosshans, D Ortiz, P Novick - Proceedings of the …, 2006 - National Acad Sciences
Rab proteins constitute the largest branch of the Ras GTPase superfamily. Rabs use the
guanine nucleotide-dependent switch mechanism common to the superfamily to regulate …
guanine nucleotide-dependent switch mechanism common to the superfamily to regulate …
Walking to work: roles for class V myosins as cargo transporters
JA Hammer III, JR Sellers - Nature reviews Molecular cell biology, 2012 - nature.com
Cells use molecular motors, such as myosins, to move, position and segregate their
organelles. Class V myosins possess biochemical and structural properties that should …
organelles. Class V myosins possess biochemical and structural properties that should …
Rab GTPases, intracellular traffic and disease
Membrane and protein traffic in the secretory and endocytic pathways is mediated by
vesicular transport. Recent studies of certain key regulators of vesicular transport, the Rab …
vesicular transport. Recent studies of certain key regulators of vesicular transport, the Rab …
Disorders of lysosome-related organelle biogenesis: clinical and molecular genetics
M Huizing, A Helip-Wooley, W Westbroek… - … Rev. Genomics Hum …, 2008 - annualreviews.org
Lysosome-related organelles (LROs) are a heterogeneous group of vesicles that share
various features with lysosomes, but are distinct in function, morphology, and composition …
various features with lysosomes, but are distinct in function, morphology, and composition …