Abstract Cyclic adenosine 3′, 5′-monophosphate (cAMP), the first second messenger to
be described, plays a central role in cell signaling in a wide variety of cell types. Over the last …

Capacitation is an important physiological pre-requisite before the sperm cell can acrosome
react and fertilize the oocyte. Recent reports from several laboratories have amply …

Reactive oxygen species (ROS), such as the superoxide anion (O2−), hydrogen peroxide
(H2O2) and nitric oxide (NO), when generated at low and controlled levels, act as second …

Capacitation is a complex series of molecular events that occurs in sperm after epididymal
maturation and confers on sperm the ability to fertilize an egg. This process can be mimicked …

The role of reactive oxygen species (ROS) as signal transduction elements in physiological
phenomena is a recent concept that changes the paradigm of these active species as …

Binding to the zona pellucida of an egg stimulates the spermatozoon to undergo the
acrosome reaction, a process that enables it to penetrate the egg. Before this binding, the …

Sperm capacitation in vitro is highly correlated with an increase in protein tyrosine
phosphorylation that is regulated by cAMP through a unique mode of signal transduction …

Testicular sperm that have undergone spermatogeneis and spermiogenesis appear mature
from a morphological standpoint but have acquired neither progressive motility nor the …

We previously demonstrated that mouse sperm capacitation is accompanied by a time-
dependent increase in protein tyrosine phosphorylation that is dependent on the presence …

Second messengers are involved in sperm fertilizing potential, as both motility and the
acrosome reaction are influenced by cAMP. Moreover, the activity of cyclic nucleotides is …