For a long time, PLS3 (plastin 3, also known as T-plastin or fimbrin) has been considered a
rather inconspicuous protein, involved in F-actin-binding and-bundling. However, in recent …

Osteoporosis, characterized by deteriorated bone microarchitecture and low bone mineral
density, is a chronic skeletal disease with high worldwide prevalence. Osteoporosis related …

Osteoporosis is a skeletal disorder with enhanced bone fragility, usually affecting the elderly.
It is very rare in children and young adults and the definition is not only based on a low BMD …

Osteoporosis is a metabolic bone disorder which increases fragility fracture risk. Elderly
individuals, especially postmenopausal women, are particularly susceptible to osteoporosis …

The limited accessibility of bone and its mineralized nature have restricted deep
investigation of its biology. Recent breakthroughs in identification of mutant proteins …

Mutations in actin-bundling protein plastin 3 (PLS3) emerged as a cause of congenital
osteoporosis, but neither the role of PLS3 in bone development nor the mechanisms …

Keratoconus (KC) is a complex corneal disorder with genetic factors involving in its
pathogenesis. The genetic etiology of KC has not been fully elucidated. In this study, we …

Osteogenesis imperfecta (OI) is a disease characterised by altered bone tissue material
properties together with abnormal micro and macro-architecture and thus bone fragility …

Recent advancements in genetic research have uncovered new forms of monogenic
osteoporosis, expanding our understanding of the molecular pathways regulating bone …

ABSTRACT Early‐onset osteoporosis (EOOP), characterized by low bone mineral density
(BMD) and fractures, affects children, premenopausal women and men aged< 50 years …