[HTML][HTML] Compartmentalized regulation of lipid signaling in oxidative stress and inflammation: Plasmalogens, oxidized lipids and ferroptosis as new paradigms of …

AM Astudillo, MA Balboa, J Balsinde - Progress in Lipid Research, 2023 - Elsevier
Perturbations in lipid homeostasis combined with conditions favoring oxidative stress
constitute a hallmark of the inflammatory response. In this review we focus on the most …

[HTML][HTML] Regulation of plasmalogen metabolism and traffic in mammals: The fog begins to lift

F Dorninger, ER Werner, J Berger… - Frontiers in Cell and …, 2022 - frontiersin.org
Due to their unique chemical structure, plasmalogens do not only exhibit distinct biophysical
and biochemical features, but require specialized pathways of biosynthesis and …

[HTML][HTML] Marine plasmalogens: A gift from the sea with benefits for age-associated diseases

S Yamashita, T Miyazawa, O Higuchi, M Kinoshita… - Molecules, 2023 - mdpi.com
Aging increases oxidative and inflammatory stress caused by a reduction in metabolism and
clearance, thus leading to the development of age-associated diseases. The quality of our …

Molecular basis of unique specificity and regulation of group VIA calcium-independent phospholipase A2 (PNPLA9) and its role in neurodegenerative diseases

D Hayashi, EA Dennis - Pharmacology & therapeutics, 2023 - Elsevier
Glycerophospholipids are major components of cell membranes and consist of a glycerol
backbone esterified with one of over 30 unique fatty acids at each of the sn-1 and sn-2 …

Membrane Association Allosterically Regulates Phospholipase A2 Enzymes and Their Specificity

VD Mouchlis, EA Dennis - Accounts of chemical research, 2022 - ACS Publications
Conspectus Water-soluble proteins as well as membrane-bound proteins associate with
membrane surfaces and bind specific lipid molecules in specific sites on the protein …

Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma

HJ Zhang, YT Chen, XL Hu, WT Cai… - Neural regeneration …, 2023 - journals.lww.com
Central nervous system (CNS) trauma, including traumatic brain injury and spinal cord
injury, has a high rate of disability and mortality, and effective treatment is currently lacking …

[HTML][HTML] Dynamics of docosahexaenoic acid utilization by mouse peritoneal macrophages

P Monge, AM Astudillo, L Pereira, MA Balboa… - Biomolecules, 2023 - mdpi.com
In this work, the incorporation of docosahexaenoic acid (DHA) in mouse resident peritoneal
macrophages and its redistribution within the various phospholipid classes were …

[HTML][HTML] Regulation of plasmalogen biosynthesis in mammalian cells and tissues

M Honsho, Y Fujiki - Brain Research Bulletin, 2023 - Elsevier
Plasmalogens are a unique family of cellular glycerophospholipids that contain a vinyl-ether
bond. Synthesis of plasmalogens is initiated in peroxisomes and completed in the …

Systematic crosstalk in plasmalogen and diacyl lipid biosynthesis for their differential yet concerted molecular functions in the cell

T Kimura, AK Kimura, RM Epand - Progress in Lipid Research, 2023 - Elsevier
Plasmalogen is a major phospholipid of mammalian cell membranes. Recently it is
becoming evident that the sn-1 vinyl-ether linkage in plasmalogen, contrasting to the ester …

[HTML][HTML] The Phospholipid Molecular Species Profile of Apostichopus japonicus Tissues Modifies through Exposure to n-3 Polyunsaturated Fatty Acid-Deficient Diet

EV Ermolenko, TV Sikorskaya, VP Grigorchuk - Marine Drugs, 2022 - mdpi.com
The sea cucumber Apostichopus japonicus, being a target species of commercial fisheries
and aquaculture, is also used as a source of biologically active compounds with high …