Design and simulation of DNA, RNA and hybrid protein–nucleic acid nanostructures with oxView

J Bohlin, M Matthies, E Poppleton, J Procyk, A Mallya… - Nature protocols, 2022 - nature.com
Molecular simulation has become an integral part of the DNA/RNA nanotechnology
research pipeline. In particular, understanding the dynamics of structures and single …

A primer on the oxDNA model of DNA: when to use it, how to simulate it and how to interpret the results

A Sengar, TE Ouldridge, O Henrich… - Frontiers in Molecular …, 2021 - frontiersin.org
The oxDNA model of Deoxyribonucleic acid has been applied widely to systems in biology,
biophysics and nanotechnology. It is currently available via two independent open source …

DNA-based programmable gate arrays for general-purpose DNA computing

H Lv, N Xie, M Li, M Dong, C Sun, Q Zhang, L Zhao… - Nature, 2023 - nature.com
The past decades have witnessed the evolution of electronic and photonic integrated
circuits, from application specific to programmable,. Although liquid-phase DNA circuitry …

A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower

M Centola, E Poppleton, S Ray, M Centola… - Nature …, 2024 - nature.com
Molecular engineering seeks to create functional entities for modular use in the bottom-up
design of nanoassemblies that can perform complex tasks. Such systems require fuel …

A reversibly gated protein-transporting membrane channel made of DNA

S Dey, A Dorey, L Abraham, Y Xing, I Zhang… - Nature …, 2022 - nature.com
Controlled transport of biomolecules across lipid bilayer membranes is of profound
significance in biological processes. In cells, cargo exchange is mediated by dedicated …

Rapid prototyping of arbitrary 2D and 3D wireframe DNA origami

H Jun, X Wang, MF Parsons, WP Bricker… - Nucleic acids …, 2021 - academic.oup.com
Wireframe DNA origami assemblies can now be programmed automatically from the top-
down using simple wireframe target geometries, or meshes, in 2D and 3D, using either rigid …

Design, optimization and analysis of large DNA and RNA nanostructures through interactive visualization, editing and molecular simulation

E Poppleton, J Bohlin, M Matthies… - Nucleic acids …, 2020 - academic.oup.com
This work seeks to remedy two deficiencies in the current nucleic acid nanotechnology
software environment: the lack of both a fast and user-friendly visualization tool and a …

A versatile DNA origami-based plasmonic nanoantenna for label-free single-molecule surface-enhanced Raman spectroscopy

K Tapio, A Mostafa, Y Kanehira, A Suma, A Dutta… - ACS …, 2021 - ACS Publications
DNA origami technology allows for the precise nanoscale assembly of chemical entities that
give rise to sophisticated functional materials. We have created a versatile DNA origami …

OxDNA. org: a public webserver for coarse-grained simulations of DNA and RNA nanostructures

E Poppleton, R Romero, A Mallya… - Nucleic acids …, 2021 - academic.oup.com
OxDNA and oxRNA are popular coarse-grained models used by the DNA/RNA
nanotechnology community to prototype, analyze and rationalize designed DNA and RNA …

Environment‐dependent stability and mechanical properties of DNA origami six‐helix bundles with different crossover spacings

Y Xin, P Piskunen, A Suma, C Li, H Ijäs, S Ojasalo… - Small, 2022 - Wiley Online Library
The internal design of DNA nanostructures defines how they behave in different
environmental conditions, such as endonuclease‐rich or low‐Mg2+ solutions. Notably, the …