Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
RA Nixon, DC Rubinsztein - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …
Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
DA Gillett, RL Wallings, O Uriarte Huarte… - Journal of …, 2023 - Springer
Background Alterations in progranulin (PGRN) expression are associated with multiple
neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer's …
neurodegenerative diseases (NDs), including frontotemporal dementia (FTD), Alzheimer's …
Multiomics Evaluation of Human iPSCs and iPSC-Derived Neurons
Human induced pluripotent stem cells (iPSCs) can be differentiated into neurons, providing
living human neurons to model brain diseases. However, it is unclear how different types of …
living human neurons to model brain diseases. However, it is unclear how different types of …
CRISPRi: a way to integrate iPSC-derived neuronal models
SNJ Franks, R Heon-Roberts… - Biochemical Society …, 2024 - portlandpress.com
The genetic landscape of neurodegenerative diseases encompasses genes affecting
multiple cellular pathways which exert effects in an array of neuronal and glial cell-types …
multiple cellular pathways which exert effects in an array of neuronal and glial cell-types …
Rescue of FTLD-associated TDP-43 pathology and neurodegeneration by peripheral AAV-mediated expression of brain-penetrant progranulin
M Reich, MJ Simon, B Polke, G Werner, C Schrader… - bioRxiv, 2023 - biorxiv.org
Progranulin (PGRN) haploinsufficiency is a major risk factor for frontotemporal lobar
degeneration with TDP-43 pathology (FTLD-GRN). Multiple therapeutic strategies are in …
degeneration with TDP-43 pathology (FTLD-GRN). Multiple therapeutic strategies are in …
[HTML][HTML] A specific and portable gene expression program underlies antigen archiving by lymphatic endothelial cells
RM Sheridan, TA Doan, C Lucas, TS Forward… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Antigens from protein subunit vaccination traffic from the tissue to the draining lymph node,
either passively via the lymph or carried by dendritic cells at the local injection site. Lymph …
either passively via the lymph or carried by dendritic cells at the local injection site. Lymph …
Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Correction: Multi-modal proteomic characterization of lysosomal function and proteostasis in
progranulin-deficient neurons - PMC Back to Top Skip to main content NIH NLM Logo Access …
progranulin-deficient neurons - PMC Back to Top Skip to main content NIH NLM Logo Access …