Anxiolytic and anxiogenic? How the transcription factor MEF2 might explain the manifold behavioral effects of oxytocin
B Jurek, M Meyer - Frontiers in endocrinology, 2020 - frontiersin.org
The neuromodulator oxytocin, since its first synthesis by du Vigneaud in 1953, has mainly
been associated with beneficial physiological effects, as well as positive social and …
been associated with beneficial physiological effects, as well as positive social and …
[HTML][HTML] Myocyte enhancer factor 2A plays a central role in the regulatory networks of cellular physiopathology
B Liu, WC Ou, L Fang, CW Tian, Y Xiong - Aging and Disease, 2023 - ncbi.nlm.nih.gov
Cell regulatory networks are the determinants of cellular homeostasis. Any alteration to
these networks results in the disturbance of cellular homeostasis and induces cells towards …
these networks results in the disturbance of cellular homeostasis and induces cells towards …
Chronic oxytocin-driven alternative splicing of Crfr2α induces anxiety
J Winter, M Meyer, I Berger, M Royer, M Bianchi… - Molecular …, 2023 - nature.com
The neuropeptide oxytocin (OXT) has generated considerable interest as potential treatment
for psychiatric disorders, including anxiety and autism spectrum disorders. However, the …
for psychiatric disorders, including anxiety and autism spectrum disorders. However, the …
Structure-function relationships of the disease-linked A218T oxytocin receptor variant
Various single nucleotide polymorphisms (SNPs) in the oxytocin receptor (OXTR) gene have
been associated with behavioral traits, autism spectrum disorder (ASD) and other diseases …
been associated with behavioral traits, autism spectrum disorder (ASD) and other diseases …
Functional involvement of septal miR-132 in extinction and oxytocin-mediated reversal of social fear
A Bludau, U Schwartz, DM Zeitler, M Royer… - Molecular …, 2023 - nature.com
Social interactions are critical for mammalian survival and evolution. Dysregulation of social
behavior often leads to psychopathologies such as social anxiety disorder, denoted by …
behavior often leads to psychopathologies such as social anxiety disorder, denoted by …
Abnormal neuronal morphology and altered synaptic proteins are restored by oxytocin in autism-related SHANK3 deficient model
A Reichova, Z Bacova, S Bukatova… - Molecular and Cellular …, 2020 - Elsevier
Oxytocin has been suggested as a potential therapeutic agent in autism and other
neuropsychiatric conditions. Although, the link between the deficit in “SH3 domain and …
neuropsychiatric conditions. Although, the link between the deficit in “SH3 domain and …
Neuronal morphology alterations in autism and possible role of oxytocin
H El Falougy, B Filova, D Ostatnikova, Z Bacova… - Endocrine …, 2019 - sciendo.com
Current understanding of the neuroanatomical abnormalities in autism includes gross
anatomical changes in several brain areas and microstructural alterations in neuronal cells …
anatomical changes in several brain areas and microstructural alterations in neuronal cells …
[PDF][PDF] Cell proliferation and anti-oxidant effects of oxytocin and oxytocin receptors: role of extracellular signal-regulating kinase in astrocyte-like cells
Objectives. Oxytocin (OXT) participates in various physiological functions ranging from
reproduction to social and non-social behaviors. Recent studies indicate that OXT affects …
reproduction to social and non-social behaviors. Recent studies indicate that OXT affects …
Myocyte enhancer factor 2A (MEF2A) defines oxytocin-induced morphological effects and regulates mitochondrial function in neurons
M Meyer, K Kuffner, J Winter, ID Neumann… - International Journal of …, 2020 - mdpi.com
The neuropeptide oxytocin (OT) is a well-described modulator of socio-emotional traits, such
as anxiety, stress, social behavior, and pair bonding. However, when dysregulated, it is …
as anxiety, stress, social behavior, and pair bonding. However, when dysregulated, it is …
Oxytocin accelerates tight junction formation and impairs cellular migration in 3D spheroids: evidence from Gapmer-induced exon skipping
Oxytocin (OXT) is a neuropeptide that has been associated with neurological diseases like
autism, a strong regulating activity on anxiety and stress-related behavior, physiological …
autism, a strong regulating activity on anxiety and stress-related behavior, physiological …