Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …

Enhanced long-term survival rates of young women with cancer and advances in
reproductive medicine and cryobiology have culminated in an increased interest in fertility …

BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

Fertility preservation is an emerging discipline, which is of substantial clinical value in the
care of young patients with cancer. Chemotherapy and radiation may induce ovarian …

BACKGROUND Within the ovary, oocytes are stored in long-lived structures called
primordial follicles, each comprising a meiotically arrested oocyte, surrounded by somatic …

It is well established that DNA-damaging chemotherapies can cause infertility and ovarian
endocrine failure by depleting the ovarian reserve of primordial follicles. Currently, no …

Cancer therapy can cause off-target effects including ovarian damage, which may result in
primary ovarian insufficiency in girls and premenopausal women. Loss of ovarian follicles …

Female gametes are stored in the ovary in structures called primordial follicles, the supply of
which is non-renewable. It is well established that DNA-damaging cancer treatments can …

Recent advances in our understanding of the mechanisms underlying the impact of cytotoxic
drugs on the ovary have opened up new directions for the protection of the ovary from …

As the number of young cancer survivors increases, quality of life after cancer treatment is
becoming an ever more important consideration. According to a report from the American …