I'm coming to GEF you: Regulation of RhoGEFs during cell migration

SM Goicoechea, S Awadia… - Cell adhesion & …, 2014 - Taylor & Francis
Cell migration is a highly regulated multistep process that requires the coordinated
regulation of cell adhesion, protrusion, and contraction. These processes require numerous …

RHOA in gastric cancer: functional roles and therapeutic potential

S Nam, JH Kim, DH Lee - Frontiers in genetics, 2019 - frontiersin.org
The well-known signal mediator and small GTPase family member, RHOA, has now been
associated with the progression of specific malignancies. In this review, we appraise the …

Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis?

AK Exadaktylos, DJ Buggy, DC Moriarty… - …, 2006 - pmc.ncbi.nlm.nih.gov
Background: Regional anesthesia is known to prevent or attenuate the surgical stress
response; thus, inhibiting surgical stress by paravertebral anesthesia might attenuate …

[HTML][HTML] Divergent transcription: a driving force for new gene origination?

X Wu, PA Sharp - Cell, 2013 - cell.com
The mammalian genome is extensively transcribed, a large fraction of which is divergent
transcription from promoters and enhancers that is tightly coupled with active gene …

AAV-Net1 facilitates the trans-differentiation of supporting cells into hair cells in the murine cochlea

L Zhang, Y Fang, F Tan, F Guo, Z Zhang, N Li… - Cellular and Molecular …, 2023 - Springer
Mechanosensitive hair cells (HCs) in the cochlear sensory epithelium are critical for sound
detection and transduction. Mammalian HCs in the cochlea undergo cytogenesis during …

Direct effect of morphine on breast cancer cell function in vitro: role of the NET1 gene

P Ecimovic, D Murray, P Doran… - British journal of …, 2011 - academic.oup.com
Background Experimental data suggest that postoperative analgesia in general and opioids
in particular may affect the risk of metastases after primary cancer surgery. Perioperative …

Propofol and bupivacaine in breast cancer cell function in vitro–role of the NET1 gene

P Ecimovic, D Murray, P Doran, DJ Buggy - Anticancer research, 2014 - ar.iiarjournals.org
Background: It has been hypothesized that anaesthesia during primary breast cancer
surgery may influence recurrence or metastasis. Effects of anaesthetic drugs on breast …

MYEOV increases HES1 expression and promotes pancreatic cancer progression by enhancing SOX9 transactivity

E Liang, Y Lu, Y Shi, Q Zhou, F Zhi - Oncogene, 2020 - nature.com
Emerging evidence indicates that myeloma overexpressed (MYEOV) is an oncogene and
plays crucial roles in multiple human cancers. However, its roles in the development of …

NET1-mediated RhoA activation facilitates lysophosphatidic acid-induced cell migration and invasion in gastric cancer

D Murray, G Horgan, P Macmathuna, P Doran - British journal of cancer, 2008 - nature.com
The most lethal aspects of gastric adenocarcinoma (GA) are its invasive and metastatic
properties. This aggressive phenotype remains poorly understood. We have recently …

MYEOV functions as an amplified competing endogenous RNA in promoting metastasis by activating TGF-β pathway in NSCLC

L Fang, S Wu, X Zhu, J Cai, J Wu, Z He, L Liu, M Zeng… - Oncogene, 2019 - nature.com
Non-small cell lung cancer (NSCLC) remains a major cause of death worldwide. As
metastatic disease is primarily responsible for the poor clinical outcome of NSCLC, it is …