Bile salt biotransformations by human intestinal bacteria

JM Ridlon, DJ Kang, PB Hylemon - Journal of lipid research, 2006 - ASBMB
Secondary bile acids, produced solely by intestinal bacteria, can accumulate to high levels
in the enterohepatic circulation of some individuals and may contribute to the pathogenesis …

Enzymes of the biosynthesis of octadecanoid‐derived signalling molecules

F Schaller - Journal of experimental botany, 2001 - academic.oup.com
It is known that octadecanoids, ie jasmonic acid and related compounds are involved in
plant defence reactions against (1) microbial pathogens,(2) herbivores and (3) damage by …

Active efflux of bile salts by Escherichia coli

DG Thanassi, LW Cheng, H Nikaido - Journal of bacteriology, 1997 - Am Soc Microbiol
Enteric bacteria such as Escherichia coli must tolerate high levels of bile salts, powerful
detergents that disrupt biological membranes. The outer membrane barrier of gram-negative …

The 7-α-dehydroxylation pathway: An integral component of gut bacterial bile acid metabolism and potential therapeutic target

JL Wise, BP Cummings - Frontiers in Microbiology, 2023 - frontiersin.org
The gut microbiome plays a significant role in maintaining host metabolic health through the
production of metabolites. Comprising one of the most abundant and diverse forms of gut …

Old yellow enzyme at 2 Å resolution: overall structure, ligand binding, and comparison with related flavoproteins

KM Fox, PA Karplus - Structure, 1994 - cell.com
Background: Old yellow enzyme (OYE) was the first flavoenzyme purified, but its function is
still unknown. Nevertheless, the NADPH oxidase activity, the flavin mononucleotide …

The Hylemon-Björkhem pathway of bile acid 7-dehydroxylation: history, biochemistry, and microbiology

JM Ridlon, SL Daniel, HR Gaskins - Journal of Lipid Research, 2023 - ASBMB
Bile acids are detergents derived from cholesterol that function to solubilize dietary lipids,
remove cholesterol from the body, and act as nutrient signaling molecules in numerous …

Identification and Characterization of a Bile Acid 7α-Dehydroxylation Operon in Clostridium sp. Strain TO-931, a Highly Active 7α-Dehydroxylating Strain Isolated from …

JE Wells, PB Hylemon - Applied and environmental microbiology, 2000 - Am Soc Microbiol
Clostridium sp. strain TO-931 can rapidly convert the primary bile acid cholic acid to a
potentially toxic compound, deoxycholic acid. Mixed oligonucleotide probes were used to …

Assignment of Eubacterium sp. VPI 12708 and related strains with high bile acid 7alpha-dehydroxylating activity to Clostridium scindens and proposal of Clostridium …

M Kitahara, F Takamine… - … journal of systematic …, 2000 - microbiologyresearch.org
Unknown Eubacterium-like organisms VPI 12708 and five strains (Y-1113, I-10, M-18, TH-82
and 36S) had high bile acid 7alpha-dehydroxylating activity; the unknown Clostridium-like …

Biotransformation of monoterpenes, bile acids, and other isoprenoids in anaerobic ecosystems

PB Hylemon, J Harder - FEMS microbiology reviews, 1998 - academic.oup.com
Isoprenoic compounds play a major part in the global carbon cycle. Biosynthesis and
mineralization by aerobic bacteria have been intensively studied. This review describes our …

Isolation and characterization of a bile acid inducible 7α-dehydroxylating operon in Clostridium hylemonae TN271

JM Ridlon, DJ Kang, PB Hylemon - Anaerobe, 2010 - Elsevier
Primary bile acids are synthesized from cholesterol in the liver, conjugated to either glycine
or taurine and secreted into bile. Bile salts undergo enterohepatic circulation several times …