The analysis of blood spotted and dried on a matrix (ie,“dried blood spot” or DBS) has been
used since the 1960s in clinical chemistry; mostly for neonatal screening. Since then, many …

Context: Serum thyroglobulin (Tg) measurements are central to the management of patients
treated for differentiated thyroid carcinoma. For decades, Tg measurements have relied on …

Microtubule-associated Tau proteins are major actors in neurological disorders, the so-
called tauopathies. In some of them, and specifically in Alzheimer's disease (AD) …

Developments in immunoassays and mass spectrometry have independently influenced
diagnostic technology. However, both techniques possess unique strengths and limitations …

Alzheimer's disease (AD) is the most common cause of dementia. Biomarkers are required
to identify individuals in the preclinical phase, explain phenotypic diversity, measure …

Over the past decades, the genome and proteome have been widely explored for biomarker
discovery and personalized medicine. However, there is still a large need for improved …

An elevated low-density lipoprotein cholesterol concentration is a classical risk factor for
cardiovascular disease. This has led to pharmacotherapy in patients with atherosclerotic …

The pipeline of biomarker translation from bench to bedside is challenging and limited
biomarkers have been adopted to routine clinical care. Ideally, biomarker research and …

Protein glycosylation fingerprints are widely recognized as potential markers for disease
states, and indeed differential glycosylation has been identified in multiple types of …

Clinically actionable quantification of protein biomarkers by mass spectrometry (MS)
requires analytical performance in concordance with quality specifications for diagnostic …