Humans are virtually identical in their genetic makeup, yet the small differences in our DNA
give rise to tremendous phenotypic diversity across the human population. By contrast, the …

Recent reports have suggested that the establishment of industrially relevant enzyme
collections from environmental genomes has become a routine procedure. Across the …

Microbial genome sequencing projects produce numerous sequences of deduced proteins,
only a small fraction of which have been or will ever be studied experimentally. This leaves …

Experimental studies of Escherichia coli K-12 MG1655 often implicate poorly annotated
genes in cellular phenotypes. However, we lack a systematic understanding of these genes …

Shotgun metatranscriptomics (MTX) is an increasingly practical way to survey microbial
community gene function and regulation at scale. This review begins by summarizing the …

The green alga Chlamydomonas reinhardtii is a popular unicellular organism for studying
photosynthesis, cilia biogenesis, and micronutrient homeostasis. Ten years since its …

Esterases receive special attention because of their wide distribution in biological systems
and environments and their importance for physiology and chemical synthesis. The …

Abstract Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial
Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine …

HAMAP (High-quality Automated and Manual Annotation of Proteins—available at
http://hamap. expasy. org/) is a system for the automatic classification and annotation of …

To the Editor—Much of life science research revolves around understanding the biological
function of proteins. Some proteins, such as the tumor suppressor p53, have been studied …