CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

Bone remodeling is essential for the repair and replacement of damaged and old bone. The
major principle underlying this process is that osteoclast-mediated resorption of a quantum …

Screening gene function in vivo is a powerful approach to discover novel drug targets. We
present high-throughput screening (HTS) data for 3 762 distinct global gene knockout (KO) …

Osteopetrosis is a group of genetic bone disorders characterized by increased bone density
and defective bone resorption. Osteopetrosis presents a series of clinical manifestations …

The phosphatase FIG4 and the scaffold protein VAC14 function in the biosynthesis of PI (3,
5) P2, a signaling lipid that inhibits the lysosomal chloride transporter ClC-7. Loss-of …

After the discovery of abundant v-ATPase complexes in the osteoclast ruffled membrane it
was obvious that in parallel a negative counter-ion needs to be transported across this …

Rare skeletal diseases are still in need of proper clinically available transfection agents as
the major challenge for first-in-human translation relates to intrinsic difficulty in targeting …

Osteopetroses are a heterogeneous group of rare genetic bone diseases sharing the
common hallmarks of reduced osteoclast activity, increased bone mass and high bone …

The regulation of luminal ion concentrations is critical for the function of, and transport
between intracellular organelles. The importance of the acidic pH in the compartments of the …

Genetic disorders of the skeleton encompass a diverse group of bone diseases differing in
clinical characteristics, severity, incidence and molecular etiology. Of particular interest are …