The calcium signal is a powerful and multifaceted tool by which cells can achieve specific
outcomes. Cellular machinery important in tumour progression is often driven or influenced …

Autophagy is a basic catabolic process, serving as an internal engine during responses to
various cellular stresses. As regards cancer, autophagy may play a tumor suppressive role …

Abstract TMPRSS2–ERG (T2E) structural rearrangements typify∼ 50% of prostate tumors
and result in overexpression of the ERG transcription factor. Using chromatin, genomic and …

Voltage-gated calcium channels (VGCCs) comprise five subtypes: The L‑type; R‑type; N‑
type; P/Q‑type; and T‑type, which are encoded by α1 subunit genes. Calcium ion channels …

Mounting in vitro, in vivo and clinical evidence suggest an important role for filopodia in
driving cancer cell invasion. Using a high-throughput microscopic-based drug screen, we …

Changes of the electrical charges across the surface cell membrane are absolutely
necessary to maintain cellular homeostasis in physiological as well as in pathological …

Calcium (Ca2+) signaling and the modulation of intracellular calcium ([Ca2+] i) levels play
critical roles in several key processes that regulate cellular survival, growth, differentiation …

The study of calcium channels in molecular mechanisms of cancer transformation is still a
novel area of research. Several studies, mostly conducted on cancer cell lines, however …

Cancer, the second cause of death worldwide, is characterized by several common criteria,
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …

Voltage-gated calcium channels (VGCCs) are well documented to play roles in cell
proliferation, migration, and apoptosis; however, whether VGCCs regulate the onset and …