Almost all patients with hepatocellular carcinoma (HCC), a major type of primary liver
cancer, also have liver cirrhosis, the severity of which hampers effective treatment for HCC …

In the early 1900s, numerous seminal publications reported that high rates of cancer
occurred in certain occupations. During this period, work with infectious agents produced …

Hepatocellular carcinoma (HCC) is a leading cause of cancer mortality and has an
increasing incidence worldwide. HCC can be induced by multiple etiologies, is influenced …

The hepatitis B virus (HBV) is a small enveloped DNA virus, which primarily infects
hepatocytes and causes acute and persistent liver disease. Epidemiological studies have …

Transgenic mice that overproduce the hepatitis B virus large envelope polypeptide and
accumulate toxic quantities of hepatitis B surface antigen (HBsAg) within the hepatocyte …

There is little information regarding the molecular mechanisms of hepatocarcinogenesis. We
studied the p53 gene at the DNA, RNA, and protein level in seven human hepatocellular …

Abstract HEPATITIS B virus (HBV) DNA frequently integrates into the genome of human
primary liver cancer cells1–4, but the significance of this integration in liver carcinogenesis is …

Background and aims: Hepatitis B virus (HBV) DNA integration into or close to cellular
genes is frequently detected in HBV positive hepatocellular carcinomas (HCC). We have …

We studied the development of liver tumors in male HBx gene transgenic mice. Of two
lineages studied, in the lineage with the lowest HBx gene expression liver tumors developed …

Hepatocellular carcinoma (HCC) is the most common histological form of primary liver
cancer, the tumor cells having retained features of hepatocytic differentiation. It is important …