Antibiotic perturbations to the gut microbiome

SRS Fishbein, B Mahmud, G Dantas - Nature Reviews Microbiology, 2023 - nature.com
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health

K Oliphant, E Allen-Vercoe - Microbiome, 2019 - Springer
The human gut microbiome is a critical component of digestion, breaking down complex
carbohydrates, proteins, and to a lesser extent fats that reach the lower gastrointestinal tract …

The evolution of the use of faecal microbiota transplantation and emerging therapeutic indications

JR Allegretti, BH Mullish, C Kelly, M Fischer - The Lancet, 2019 - thelancet.com
Developments in high-throughput microbial genomic sequencing and other systems biology
techniques have given novel insight into the potential contribution of the gut microbiota to …

The promise of the gut microbiome as part of individualized treatment strategies

DA Schupack, RAT Mars, DH Voelker… - Nature reviews …, 2022 - nature.com
Variability in disease presentation, progression and treatment response has been a central
challenge in medicine. Although variability in host factors and genetics are important, it has …

An overview on fecal branched short-chain fatty acids along human life and as related with body mass index: associated dietary and anthropometric factors

D Rios-Covian, S González, AM Nogacka… - Frontiers in …, 2020 - frontiersin.org
Short-chain fatty acids (SCFA) are the main bacterial products of the catabolism of
carbohydrates and proteins in the gut, and their role is essential in host–microbiota …

Faecal microbiota transplantation for Clostridioides difficile: mechanisms and pharmacology

A Khoruts, C Staley, MJ Sadowsky - Nature Reviews Gastroenterology & …, 2021 - nature.com
Faecal microbiota transplantation (FMT) has emerged as a remarkably successful treatment
for recurrent Clostridioides difficile infection that cannot be cured with antibiotics alone …

Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection

BH Mullish, JAK McDonald, A Pechlivanis, JR Allegretti… - Gut, 2019 - gut.bmj.com
Objective Faecal microbiota transplant (FMT) effectively treats recurrent Clostridioides
difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile …

Recipient factors in faecal microbiota transplantation: one stool does not fit all

C Danne, N Rolhion, H Sokol - Nature Reviews Gastroenterology & …, 2021 - nature.com
Faecal microbiota transplantation (FMT) is a promising therapy for chronic diseases
associated with gut microbiota alterations. FMT cures 90% of recurrent Clostridioides difficile …

[HTML][HTML] Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2

JL Fachi, C Sécca, PB Rodrigues, FCP Mato… - Journal of Experimental …, 2020 - rupress.org
Antibiotic-induced dysbiosis is a key predisposing factor for Clostridium difficile infections
(CDIs), which cause intestinal disease ranging from mild diarrhea to pseudomembranous …

Dynamic balancing of intestinal short-chain fatty acids: The crucial role of bacterial metabolism

Y Xu, Y Zhu, X Li, B Sun - Trends in Food Science & Technology, 2020 - Elsevier
Background Short-chain fatty acids (SCFAs) play important physiological roles in human
health. Adverse effects on health are known with a low or excessive concentration of SCFAs …