Chemical syntheses of bioinspired and biomimetic polymers toward biobased materials

MS Ganewatta, Z Wang, C Tang - Nature Reviews Chemistry, 2021 - nature.com
The rich structures and hierarchical organizations in nature provide many sources of
inspiration for advanced material designs. We wish to recapitulate properties such as high …

Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation

Y Jiang, Y Chen, Z Song, Z Tan, J Cheng - Advanced Drug Delivery …, 2021 - Elsevier
The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …

Addressing MRSA infection and antibacterial resistance with peptoid polymers

J Xie, M Zhou, Y Qian, Z Cong, S Chen… - Nature …, 2021 - nature.com
Abstract Methicillin-Resistant Staphylococcus aureus (MRSA) induced infection calls for
antibacterial agents that are not prone to antimicrobial resistance. We prepare protease …

Peptide design principles for antimicrobial applications

MDT Torres, S Sothiselvam, TK Lu… - Journal of molecular …, 2019 - Elsevier
The increased incidence of bacterial resistance to available antibiotics represents a major
global health problem and highlights the need for novel anti-infective therapies …

Secondary amine pendant β-peptide polymers displaying potent antibacterial activity and promising therapeutic potential in treating MRSA-induced wound infections …

Y Qian, S Deng, Z Cong, H Zhang, Z Lu… - Journal of the …, 2022 - ACS Publications
Interest in developing antibacterial polymers as synthetic mimics of host defense peptides
(HPDs) has accelerated in recent years to combat antibiotic-resistant bacterial infections …

[HTML][HTML] Therapeutic strategies against bacterial biofilms

Y Bi, G Xia, C Shi, J Wan, L Liu, Y Chen, Y Wu… - Fundamental …, 2021 - Elsevier
The emergence of multi-drug resistance makes bacterial infection a major threat to public
health and economy. The formation of bacterial biofilms is one of the main reasons of …

A macromolecular approach to eradicate multidrug resistant bacterial infections while mitigating drug resistance onset

W Chin, G Zhong, Q Pu, C Yang, W Lou… - Nature …, 2018 - nature.com
Polymyxins remain the last line treatment for multidrug-resistant (MDR) infections. As
polymyxins resistance emerges, there is an urgent need to develop effective antimicrobial …

Antimicrobial polymers: the potential replacement of existing antibiotics?

NF Kamaruzzaman, LP Tan, RH Hamdan… - International Journal of …, 2019 - mdpi.com
Antimicrobial resistance is now considered a major global challenge; compromising medical
advancements and our ability to treat infectious disease. Increased antimicrobial resistance …

Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies

Z Si, W Zheng, D Prananty, J Li, CH Koh, ET Kang… - Chemical …, 2022 - pubs.rsc.org
The growing prevalence of antimicrobial drug resistance in pathogenic bacteria is a critical
threat to global health. Conventional antibiotics still play a crucial role in treating bacterial …

Host defense peptide mimicking antimicrobial amino acid polymers and beyond: Design, synthesis and biomedical applications

Y Wu, K Chen, J Wang, M Chen, Y Chen, Y She… - Progress in Polymer …, 2023 - Elsevier
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …