Functional classification and experimental dissection of long noncoding RNAs
F Kopp, JT Mendell - Cell, 2018 - cell.com
Over the last decade, it has been increasingly demonstrated that the genomes of many
species are pervasively transcribed, resulting in the production of numerous long noncoding …
species are pervasively transcribed, resulting in the production of numerous long noncoding …
The functions and unique features of long intergenic non-coding RNA
JD Ransohoff, Y Wei, PA Khavari - Nature reviews Molecular cell …, 2018 - nature.com
Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …
them from mRNA-encoding genes and exercise functions such as remodelling chromatin …
Non-coding RNAs and potential therapeutic targeting in cancer
Recent advances have begun to clarify the physiological and pathological roles of non-
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …
Long non-coding RNAs in cancer: implications for diagnosis, prognosis, and therapy
Y Qian, L Shi, Z Luo - Frontiers in medicine, 2020 - frontiersin.org
Long non-coding RNAs (lncRNAs) are major components of cellular transcripts that are
arising as important players in various biological pathways. They have received extensive …
arising as important players in various biological pathways. They have received extensive …
Long noncoding RNAs in cancer pathways
AM Schmitt, HY Chang - Cancer cell, 2016 - cell.com
Genome-wide cancer mutation analyses are revealing an extensive landscape of functional
mutations within the noncoding genome, with profound effects on the expression of long …
mutations within the noncoding genome, with profound effects on the expression of long …
A peptide encoded by a putative lncRNA HOXB-AS3 suppresses colon cancer growth
A substantial fraction of eukaryotic transcripts are considered long non-coding RNAs
(lncRNAs), which regulate various hallmarks of cancer. Here, we discovered that the lncRNA …
(lncRNAs), which regulate various hallmarks of cancer. Here, we discovered that the lncRNA …
Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets
T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …
the origin, course of action and treatment of any disease state is essential. A microscopic …
Long non-coding RNA LINC00680 functions as a ceRNA to promote esophageal squamous cell carcinoma progression through the miR-423-5p/PAK6 axis
ST Xue, B Zheng, SQ Cao, JC Ding, GS Hu, W Liu… - Molecular cancer, 2022 - Springer
Background Esophageal squamous cell carcinoma (ESCC) is a common invasive
malignancy worldwide with poor clinical outcomes. Increasing amount of long non-coding …
malignancy worldwide with poor clinical outcomes. Increasing amount of long non-coding …
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
INTRODUCTION The human genome contains tens of thousands of loci that produce long
noncoding RNAs (lncRNAs), transcripts that have no apparent protein-coding potential. A …
noncoding RNAs (lncRNAs), transcripts that have no apparent protein-coding potential. A …
Mechanisms of long noncoding RNA function in development and disease
SU Schmitz, P Grote, BG Herrmann - Cellular and molecular life sciences, 2016 - Springer
Since decades it has been known that non-protein-coding RNAs have important cellular
functions. Deep sequencing recently facilitated the discovery of thousands of novel …
functions. Deep sequencing recently facilitated the discovery of thousands of novel …