Recent developments in G-quadruplex binding ligands and specific beacons on smart fluorescent sensor for targeting metal ions and biological analytes
The G-quadruplex structure is crucial in several biological processes, including DNA
replication, transcription, and genomic maintenance. G-quadruplex-based fluorescent …
replication, transcription, and genomic maintenance. G-quadruplex-based fluorescent …
A modular aldol approach for internal fluorescent molecular rotor chalcone surrogates for DNA biosensing applications
RE Johnson, MT Murray, LJ Bycraft, SD Wetmore… - Chemical …, 2023 - pubs.rsc.org
Fluorescent molecular rotors (FMRs) are critical tools for probing nucleic acid structure and
function. Many valuable FMRs have been incorporated into oligonucleotides, although the …
function. Many valuable FMRs have been incorporated into oligonucleotides, although the …
Promoter G-quadruplex binding styryl benzothiazolium derivative for applications in ligand affinity ranking and as ethidium bromide substitute in gel staining
RK Patidar, K Tiwari, R Tiwari… - ACS Applied Bio …, 2023 - ACS Publications
Fluorescent compounds that can preferentially interact with certain nucleic acids are of great
importance in new drug discovery in a multitude of functions including fluorescence-based …
importance in new drug discovery in a multitude of functions including fluorescence-based …
Thieno[3,2-b]thiophene for the Construction of Far-Red Molecular Rotor Hemicyanines as High-Affinity DNA Aptamer Fluorogenic Reporters
The construction of far-red fluorescent molecular rotors (FMRs) is an imperative task for
developing nucleic acid stains that have superior compatibility with cellular systems and …
developing nucleic acid stains that have superior compatibility with cellular systems and …
Unlocking Pb2+ Sensing Potential in a DNA G-Quadruplex via Loop Modification with Fluorescent Chalcone Surrogates
RE Johnson, MT Murray, DJ Roby, LJ Bycraft… - ACS …, 2023 - ACS Publications
The ability of guanine (G)-rich DNA to bind toxic lead (Pb2+) ions within a G-quadruplex
(GQ) motif is a leading DNA biosensor strategy. A major analytical hurdle for GQ detection of …
(GQ) motif is a leading DNA biosensor strategy. A major analytical hurdle for GQ detection of …
Harnessing a 4-Formyl-Aniline Handle to Tune the Stability of a DNA Aptamer–Protein Complex via Fluorescent Surrogates
RE Johnson, MT Murray, LJ Bycraft, P Myler… - Bioconjugate …, 2023 - ACS Publications
Interactions between DNA aptamers and protein targets hold promise for the development of
pharmaceuticals and diagnostics. As such, the utilization of fluorescent nucleobase …
pharmaceuticals and diagnostics. As such, the utilization of fluorescent nucleobase …
Atom‐Efficient Synthesis of Trimethine Cyanines Using Formaldehyde as a Single‐Carbon Source
Herein, we present an innovative and atom‐efficient synthesis of trimethine cyanines (Cy3)
using formaldehyde (FA) as a single‐carbon reagent. The widespread application of Cy3 …
using formaldehyde (FA) as a single‐carbon reagent. The widespread application of Cy3 …
DFT studies of binding of fluoride anions with silyl-fluorescein derivatives
K Weerasinghe, L Wang - 2023 - chemrxiv.org
Fluoride is abundantly used in dental healthcare and pharmaceutical industry, it is harmful if
it is found over certain concentration in drinking water and in soil. It is therefore essential to …
it is found over certain concentration in drinking water and in soil. It is therefore essential to …
On-Strand Aldehyde Capture by an Indanone Building Block: A Modular Aldol Approach for Fluorescent Molecular Rotor Nucleobase Surrogates
R Johnson, M Murray, L Bycraft, S Wetmore… - 2022 - chemrxiv.org
Fluorescent molecular rotors (FMRs) are critical tools for monitoring nucleic acid structure
and function. Many valuable probes are capable of sitespecific insertion into …
and function. Many valuable probes are capable of sitespecific insertion into …
[PDF][PDF] Studying the Structural Dynamics and Aptamer-Ligand Interactions in the Cocaine-Binding Aptamer through Fluorescence Spectroscopy
AA Shoara - 2022 - yorkspace.library.yorku.ca
Since its first report in 1990, aptamers have been utilized in biosensor modeling
technologies. One of the most important advantages of using aptamers is the structural …
technologies. One of the most important advantages of using aptamers is the structural …