Circular RNAs and complex diseases: from experimental results to computational models
Circular RNAs (circRNAs) are a class of single-stranded, covalently closed RNA molecules
with a variety of biological functions. Studies have shown that circRNAs are involved in a …
with a variety of biological functions. Studies have shown that circRNAs are involved in a …
Updated review of advances in microRNAs and complex diseases: taxonomy, trends and challenges of computational models
Since the problem proposed in late 2000s, microRNA–disease association (MDA)
predictions have been implemented based on the data fusion paradigm. Integrating diverse …
predictions have been implemented based on the data fusion paradigm. Integrating diverse …
[HTML][HTML] VirSorter2: a multi-classifier, expert-guided approach to detect diverse DNA and RNA viruses
Background Viruses are a significant player in many biosphere and human ecosystems, but
most signals remain “hidden” in metagenomic/metatranscriptomic sequence datasets due to …
most signals remain “hidden” in metagenomic/metatranscriptomic sequence datasets due to …
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
IgA nephropathy (IgAN) is a progressive form of kidney disease defined by glomerular
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
deposition of IgA. Here we performed a genome-wide association study of 10,146 kidney …
Taxonomic assignment of uncultivated prokaryotic virus genomes is enabled by gene-sharing networks
Microbiomes from every environment contain a myriad of uncultivated archaeal and
bacterial viruses, but studying these viruses is hampered by the lack of a universal, scalable …
bacterial viruses, but studying these viruses is hampered by the lack of a universal, scalable …
Phenotypic landscape of intestinal organoid regeneration
The development of intestinal organoids from single adult intestinal stem cells in vitro
recapitulates the regenerative capacity of the intestinal epithelium,. Here we unravel the …
recapitulates the regenerative capacity of the intestinal epithelium,. Here we unravel the …
The genetic architecture of type 2 diabetes
The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …
A review on drug repurposing applicable to COVID-19
S Dotolo, A Marabotti, A Facchiano… - Briefings in …, 2021 - academic.oup.com
Drug repurposing involves the identification of new applications for existing drugs at a lower
cost and in a shorter time. There are different computational drug-repurposing strategies and …
cost and in a shorter time. There are different computational drug-repurposing strategies and …
CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities
Cancer genomics studies have identified thousands of putative cancer driver genes.
Development of high-throughput and accurate models to define the functions of these genes …
Development of high-throughput and accurate models to define the functions of these genes …
Spectral clustering on protein-protein interaction networks via constructing affinity matrix using attributed graph embedding
The identification of protein complexes in protein-protein interaction networks is the most
fundamental and essential problem for revealing the underlying mechanism of biological …
fundamental and essential problem for revealing the underlying mechanism of biological …