The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …

Atherosclerosis remains the underlying process responsible for cardiovascular diseases
and the high mortality rates associated. This chronic inflammatory disease progresses with …

Although oxygen is a prerequisite to life, at concentrations beyond the physiological limits it
may be hazardous to the cells. Since the lungs are directly exposed to very high amounts of …

Background This study aimed to develop a deep-learning model and a risk-score system
using clinical variables to predict intensive care unit (ICU) admission and in-hospital …

Heme oxygenase-1 (HO-1), a ubiquitous inducible stress-response protein, serves a major
metabolic function in heme turnover. HO activity cleaves heme to form biliverdin-IXα, carbon …

As a by-product of heme catabolism by the heme oxygenase system, carbon monoxide (CO)
has been neglected for many years, and only recently has its role as an essential signaling …

Oxidative stress has been linked to various disease states as well as physiological aging.
The lungs are uniquely exposed to a highly oxidizing environment and have evolved several …

Epigallocatechin 3-gallate (EGC19194), the major polyphenol found in green tea, exerts
antiproliferative and proapoptotic effects in many cancer cells. However, we found that …

BACKGROUND. Acute respiratory distress syndrome (ARDS) is a prevalent disease with
significant mortality for which no effective pharmacologic therapy exists. Low-dose inhaled …

Background & aims Iron is an essential trace element to almost all organism, and the
delicate balance between host defend system and viral proliferation plays an important role …