Abstract Professor Henry Higgins in My Fair Lady said,'Why can'ta woman be more like a
man?'Perhaps unintended, such narration extends to the reality of current drug …

Significant differences that exist between the sexes affect the prevalence, incidence and
severity of a broad range of diseases and conditions. Men and women also differ in their …

Physiological, hormonal, and genetic differences between males and females affect the
prevalence, incidence, and severity of diseases and responses to therapy. Understanding …

The importance of reviewing and studying sex-based differences in pharmacologic
parameters is demonstrated by the increasing data on gender variation in drug efficacy and …

Many drugs that are substrates of CYP3A4, the major human drug–metabolizing cytochrome
P450 (CYP), show higher clearance in women than in men. Although this effect is believed …

This article reviews the information available to assist pharmacokineticists in the prediction
of metabolic drug interactions. Significant advances in this area have been made in the last …

Cytochrome P450s (CYPs) are an important family of enzymes in the metabolism of many
therapeutic agents and endogenous metabolic reactions. The CYP3A subfamily is …

Background The cytochrome P450 3A (CYP3A) isoforms are responsible for the metabolism
of a majority of therapeutic compounds, and they are abundant in the intestine and liver …

Background: The activity of various CYP isoforms is critical for maintaining the clinical
effectiveness of many medications. Therefore, determining the sex-dependent activity of …

Aims Itraconazole is a potent inhibitor of CYP3A4 activity and is often used in combination
with corticosteroids. Since the latter are partly metabolized by CYP3A4, we studied the …