Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …

The Forkhead box protein M1 (FOXM1) transcription factor is a regulator of myriad biological
processes, including cell proliferation, cell cycle progression, cell differentiation, DNA …

The FOXO3 and FOXM1 forkhead box transcription factors, functioning downstream of the
essential PI3K-Akt, Ras-ERK and JNK/p38MAPK signalling cascades, are crucial for cell …

Transcription factors (TFs) are indispensable for the modulation of various signaling
pathways associated with normal cell homeostasis and disease conditions. Among cancer …

D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-
cyclins in cancer treatment, we engineered mouse strains that allow acute and global …

Uncontrolled cell division is the hallmark of cancers. Full understanding of cell cycle
regulation would contribute to promising cancer therapies. In particular, cyclin-dependent …

Reactive oxygen species (ROS) regulate the strength and duration of signaling through
redox-dependent signal transduction pathways via the cyclic oxidation/reduction of cysteine …

FOXM1 is a transcription factor required for a wide spectrum of essential biological functions,
including DNA damage repair, cell proliferation, cell cycle progression, cell renewal, cell …

Glioblastoma multiforme (GBM) is one of the most common and aggressive types of brain
tumors. In GBM, a subpopulation of CD133-positive cancer initiating cells displays stem cell …

FOXM1 is an oncogenic transcription factor of the Forkhead family and it has a well-defined
role in cell proliferation and cell-cycle progression. Expression of FOXM1 is excluded in …