Although tigecycline is widely used in clinical practice, its efficiency and optimal dosage
regimens remain controversial. The purpose of this article was to help guide tigecycline …

In light of rising antimicrobial resistance and a decreasing number of antibiotics with novel
modes of action, it is of utmost importance to accelerate development of novel treatment …

Introduction Enterococcus faecium is a commensal microorganism that can cause infections
such as bacteremia. Incidence of ampicillin-resistant and vancomycin-susceptible E …

Introduction Older individuals face an elevated risk of developing bacterial infections. The
optimal use of antibacterial agents in this population is challenging because of age-related …

Antimicrobial resistance is a growing global health problem, and it is especially relevant
among liver transplant recipients where infections, particularly when caused by …

Background: Due to the heterogeneity of critically ill patients, the pharmacokinetics of
tigecycline are unclear, and the optimal dosing strategy is controversial. Methods: A single …

Background This study aimed to explore the risk factors for failed treatment of carbapenem-
resistant Acinetobacter baumannii ventilator-associated pneumonia (CRAB-VAP) with …

Objective: In critically ill patients, the change of pathophysiological status may affect the
pharmacokinetic (PK) process of drugs. The purpose of this study was to develop a PK …

Background: This study aimed to investigate the pharmacokinetic/pharmacodynamic
(PK/PD) target attainment of various tigecycline dosing regimens in real-world patients with …