Solid organ transplantation (SOT) has emerged from an experimental approach in the 20 th
century to now being an established and practical definitive treatment option for patients with …

Differentiation of naïve T cells into effector cells is required for optimal protection against
different classes of microbial pathogen and for the development of immune memory. Recent …

Over the past two decades, the Notch signaling pathway has been investigated as a
therapeutic target for the treatment of cancers, and more recently in the context of immune …

The evolutionarily conserved Notch signalling pathway regulates the differentiation and
function of mature T lymphocytes with major context-dependent consequences in host …

Notch ligands signal through one of four receptors on neighboring cells to mediate cell–cell
communication and control cell fate, proliferation, and survival. Although aberrant Notch …

Alloimmune T cell responses induce graft-versus-host disease (GVHD), a serious
complication of allogeneic bone marrow transplantation (allo-BMT). Although Notch …

Allogeneic transplantation of foreign organs or tissues has lifesaving potential, but can lead
to serious complications. After solid organ transplantation, immune-mediated rejection …

Chimeric antigen receptor (CAR) T cells provide a promising approach to the treatment of
hematologic malignancies and solid tumors. Flow cytometry is a powerful analytical …

Background: Transplantation is the treatment of choice for many patients with end-stage
organ disease. Despite advances in immunosuppression, long-term outcomes remain …

Although short-term outcomes have improved with modern era immunosuppression, little
progress has been made in long-term graft survival in cardiac transplantation. Antibody …