Background: Mechanical dilation of the human ventricle is known to induce arrhythmias, the
underlying ionic mechanisms, however, remain to be clarified. Methods: Ventricular …

The mechanism by which Cu 2+/Zn 2+ superoxide dismutase (SOD1) mutants lead to motor
neuron degeneration in familial amyotrophic lateral sclerosis (FALS) is unknown. We show …

Intracellular calcium-binding proteins are abundantly expressed in many neuronal
populations. Previous evidence suggests that calcium-binding proteins can modulate …

1 By applying fura‐2‐based fluorometric calcium imaging to neonatal rat hippocampal slices
we identified a developmentally regulated spontaneous neuronal activity in the CA1 region …

Cell secretion or exocytosis is a fundamental and ubiquitous cell function in which
intracellular vesicles (50À100 nm in diameter) fuse with the plasma membrane and release …

One of the challenges for modern neuroscience is to understand the rules of concerted
neuronal function in vivo. This question can be addressed using noninvasive high-resolution …

The epithelium of the urinary bladder must maintain a highly impermeable barrier despite
large variations in urine volume during bladder filling and voiding. To study how the …

The secretion of synaptic and other vesicles is a complex process involving multiple steps.
Many molecular components of the secretory apparatus have been identified, but how they …

The exocytosis of neurotransmitters is regulated by calcium and is plastic—features that
suggest specialized regulation of the basic membrane trafficking process. Here we show …

Aims/hypothesis A decrease in plasma adiponectin levels has been shown to contribute to
the development of diabetes. However, it remains uncertain whether adiponectin plays a …