Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels
of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do …

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

As the COVID-19 pandemic continues to spread, investigating the processes underlying the
interactions between SARS-CoV-2 and its hosts is of high importance. Here, we report the …

Capillarization, lack of liver sinusoidal endothelial cell (LSEC) fenestration, and formation of
an organized basement membrane not only precedes fibrosis, but is also permissive for …

The demands that are imposed on the liver as a result of its function as a metabolic organ
that extracts nutrients and clears gut-derived microbial products from the blood are met by a …

The liver has vital metabolic and clearance functions that involve the uptake of nutrients,
waste products and pathogens from the blood. In addition, its unique immunoregulatory …

Flaviviruses enter host cells by endocytosis initiated when the virus particles interact with
cell surface receptors. The current model suggests that flaviviruses use at least two different …

The adverse metabolic consequences of obesity are best predicted by the quantity of
visceral fat. Excess glucocorticoids produce visceral obesity and diabetes, but circulating …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …