Acute pancreatitis is a common indication for hospital admission, increasing in incidence,
including in children, pregnancy and the elderly. Moderately severe acute pancreatitis with …

Antisense technology is now beginning to deliver on its promise to treat diseases by
targeting RNA. Nine single-stranded antisense oligonucleotide (ASO) drugs representing …

Background Familial chylomicronemia syndrome is a genetic disorder associated with
severe hypertriglyceridemia and severe acute pancreatitis. Olezarsen reduces the plasma …

BACKGROUND Reducing the levels of triglycerides and triglyceride-rich lipoproteins
remains an unmet clinical need. Olezarsen is an antisense oligonucleotide targeting …

Recent advances in human genetics, together with a large body of epidemiologic,
preclinical, and clinical trial results, provide strong support for a causal association between …

Background Persistent chylomicronemia is a genetic recessive disorder that is classically
caused by familial chylomicronemia syndrome (FCS), but it also has multifactorial causes …

Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …

Apolipoproteins are important structural components of plasma lipoproteins that influence
vascular biology and atherosclerotic disease pathophysiology by regulating lipoprotein …

Antisense technology is beginning to deliver on the broad promise of the technology. Ten
RNA-targeted drugs including eight single-strand antisense drugs (ASOs) and two double …

Hypertriglyceridaemia is a common clinical problem. Epidemiologic and genetic studies
have established that triglyceride-rich lipoproteins (TRL) and their remnants as important …